Sleep

Question 1

Provide an example of drugs that can impair wakefullness.

Answer 1

a1 antagonists (praosin)
a1 agonists
anticholinergics
anticonvulsants
antihistamines
aniparkinsonian agents
barbituates and benzos
narcotics
psychiatric medications
Skeletal muscle relaxants

Question 2

Provide an examples of the medications that can impair sleep.

Answer 2

Corticosteroids (GABA inhibition)
Narcotics (m-opioid agonists)
Nicotinic receptor agonists (^ Ach)
Psychiatric medications (ie ^ dopamine),
Barbituates and benzos (inhibit respiritory centers).
Dalfampridine (k+ channel blockade causing increased neuronal excitability.