Chapter 13- White Cells, Lymph Nodes, Spleen, and Thymus Flashcards
What are the two essential properties that are required for the maintenance of hematopoiesis?
Pluripotency and the capacity for self-renewal (p. 581)
In follicular hyperplasia of a lymph node, which structures become prominent?
Germinal centers (p. 585)
Endemic Burkitt lymphoma is caused by what virus?
Epstein-Barr virus (p. 587)
The most common form of non-Hodgkin lymphoma is ______
Diffuse large B-Cell lymphoma (p. 596)
The two major histomorphologic patterns seen in follicular lymphomas are ____ and _____.
Small cells with irregular or cleaved nuclear contours and scant cytoplasm referred to as centrocytes AND larger cells with open nuclear chromatin, several nucleoli, and modest amount of cytoplasm referred to as centroblasts. (p. 595)
What are the five categories of the WHO classification of lymphoid neoplasms?
1) Precursor B-cell neoplasms
2) Precursor T-cell neoplasms
3) Peripheral B-cell neoplasms
4) Peripheral T-cell and natural killer cell neoplasms 5) Hodgkin lymphoma (p. 588)
Burkitt lymphoma has a characteristic histologic appearance, which is known as _______.
Starry sky pattern (p. 597)
The distinctive tumor large cells found in cases of Hodgkin lymphoma are known as _______.
Reed Sternberg cells (p. 606)
Describe the usual histologic appearance of the cells identified above.
Diagnostic Reed Sternberg cells are large cells (> or = to 45 micrometers in diameter), with multiple nuclei or a single nucleus with multiple nuclear lobes, each with a large inclusion-like nucleolus, 5-7 micrometers in diameter. (p. 607)
Lacunar variant Reed Sternberg cells are most frequently encountered in what type of Hodgkin lymphoma.
Nodular Sclerosis type (p. 608)
Name the four different subtypes of Hodgkin lymphoma.
1) Nodular Sclerosis
2) Mixed cellularity
3) Lymphocyte predominance 4) Lymphocyte depletion
5) Lymphocyte-rich (p. 608)
the most common type of Hodgkin lymphoma is _______.
Nodular sclerosis (p. 608)
Name the three categories of myeloid neoplasia.
1) Acute myelocytic leukemia, characterized by accumulation of immature myeloid cells in the bone marrow.
2) Myelodysplastic syndromes associated with ineffective hematopoiesis and associated cytopenias.
3) Myeloproliferative disorders usually associated with an increased production of one or more types of blood cells. (p. 611)
What are the three major symptoms related to depression of marrow function in ALL?
1) Anemia – fatigue
2) neutropenia – fever
3) thrombocytopenia – spontaneous mucosal and cutaneous bleeding. (p. 592)
All forms of Burkitt lymphoma are associated with translocations of the ______.
C-Myc gene on chromosome 8 (p. 597)
- What is the most common cancer of children?
Acute lymphoblastic leukemia (p. 590)