IMMUNOLOGIC TERAPHY Flashcards
What is Immunologic therapy used for
CANCER
INFECTION
AUTOINMUNE DISEASE
Immunologic Therapy mechanism of action
BINDING to specific disease’s associated molecule = DISRUPTION OF MOLECULAR MECHANISM
Bevacizumab is a Monoclonal Antibody that acts in ________
VEGF-A (Inhibition of angiogenesis)
Bevacizumab is indicated in
COLORECTAL cancer
Cervical cancer
RCC/Hepatocarcinoma/Glioblastoma
Cetuximab is a Monoclonal Antibody that acts in ________
EGFR (Proto-oncogene Tyrosine Kinase)
Cetuximab is indicated in
Colorectal cancer
Head-Neck cancer
Rituximab is a Monoclonal Antibody that acts in ________
CD20 receptor (B LYMPHOCYTES) and targets them for DESTRUCTION
Rituximab is indicated in
- Non-Hodgkin Lymphoma
+ Chronic Lymphocytic Leukemia - Rheumatoid Arthritis/Multiple Sclerosis
Trastuzumab is a Monoclonal Antibody that acts in ________
HER2 receptor
Trastuzumab is indicated in
HER2(+) Breast cancer
Gastric Adenocarcinoma
Pembrolizumab is a Monoclonal Antibody that acts in ________
PD-1 RECEPTOR (on Leukocytes) = INHIBITION of CELL-MEDIATED toxicity
PD-1 Receptor binds to __________ which is expressed in _____________
PD-1L / Some forms of cancer
PD-1L is expressed in some forms of cancer because : __________________
Prevents attack by immune system
Pembrolizumab is indicated in
METASTATIC MELANOMA
NSCLC / RCC / Urothelial carcinoma
Omalizumab is a Monoclonal Antibody that acts in ________
IgE (Inhibition of IgE)
