Leukocyte Migration Flashcards
1
Q
What is inflammation and what does it require?
How can these requirements be met?
A
2
Q
What is extravasation?
A
3
Q
What are the steps for extravasation?
A
- Rolling
- binding of self in molecules to mucin-like CAMs
- Activation
- chemo knee bind to receptors on leukocyte, triggering an activating signal
- signal induces conformational change in integrin
- Arrest/adhesion
- altered integrins adhere to ICAMs on endothelium
- Transendothelial migration
4
Q
What are CAMs and the different types?
A
5
Q
What are the steps for the initiation of extravasation?
A
6
Q
What are chemokines?
A
7
Q
What is LAD?
A
