Week 7 Flashcards
1
Q
What is the occupancy model of agonist action?
A
2
Q
What is the operational model of agonist action?
A
3
Q
What are the factors and constants of the ternary complex models?
A
4
Q
What does each species in the ternary complex models represent?
A
5
Q
What experimental evidence supports the existence of the species found in each model?
A
6
Q
How do the models inform our understanding of drug action?
A
7
Q
What are the concepts of allosteric and orthosteric binding sites?
A
8
Q
What is the mechanism of action of allosteric modulators?
A
9
Q
What are the advantages that allosteric modulators have over orthosteric ligands as therapeutic drugs?
A
10
Q
How can allosteric modulators of GPCRs be identified?
A
