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Therapeutics > Controller Meds Asthma/COPD > Flashcards

Controller Meds Asthma/COPD Flashcards

Name generic name, drug class, age group, dosage form, and adverse effects/clinical pearls

1
Q

Prevent and control inflammation

A

Inhaled corticosteroids (ICS)

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2
Q

QVAR

A

ICS
Beclomethasone
Redihaler (MDI)
5yrs-adult

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3
Q

Adverse effects for ICS

A

oral thrush, cough, dysphonia

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4
Q

Counseling tips for ICS

A

*Rinse mouth and spit after use to prevent thrush
*Most effective long-term control therapy for asthma
*May increase the risk of pneumonia in patients with COPD
*Titrate to lowest effective dose
*Budesonide (Pulmicort Respules) should use jet nebulizer and should not be mixed with other nebulizer meds
*High doses increase the risk for systemic side effect

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5
Q

Pulmicort

A

ICS
Budesonide
Flexhaler
5 yrs-Adult

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6
Q

Pulmicort Respules

A

ICS
Budesonide
Nebulizer Solution
0yr-11yrs

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7
Q

Alvesco

A

ICS
Ciclesonide
HFA
5yrs-adult

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8
Q

Flovent
ArmonAir Digihaler

A

ICS
Fluticasone Propionate
HFA, DPI, Aerosol Powder Inhaler
0yrs-adult

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9
Q

Arnuity Ellipta

A

ICS
Fluticasone Furoate
Ellipta
5yrs-adult

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10
Q

Asmanex

A

ICS
Mometasone
HFA, Twisthaler
5yrs-adult

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11
Q

Bronchial smooth muscle relaxation and inhibit hypersensitivity mediators from mast cells (histamines, leukotrienes)

A

Long Acting Beta Agonist (LABA)
(increases cAMP)

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12
Q

LABA Adverse Effects

A

tachycardia, headache, tremor, hypokalemia

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13
Q

LABA Box warning

A

*Should not be used alone for asthma management (increased risk of asthma related death)
*Increasing hospitalizations in pediatric and adolescent patients
*Prolonged QT seen with intentional overdoses
*Not for acute symptoms
*May be helpful for exercise induce bronchospasm
*Formoterol and indacaterol capsules should not be taken orally

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14
Q

LABA Peds considerations

A

Most children <4 yo cannot provide sufficient inspiratory flow for adequate lung delivery with a DPI

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15
Q

Brovana

A

LABA
Arformoterol tartrate
Nebulizer Solution
Adult COPD only

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16
Q

Perforomist

A

LABA
Formoterol
Nebulizer solution
Adult COPD only unless combo with ICS

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17
Q

Arcapta Neohaler

A

LABA
Indacaterol
Neohaler
Adult COPD only

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18
Q

Striverdi Respimat

A

LABA
Olodaterol
Respimat
Adult COPD only

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19
Q

Serevent

A

LABA
Salmeterol
Diskus
5yrs-adult

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20
Q

Blocks the bronchoconstrictor effects of ACh on M3 and M2 receptors

A

LAMA

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21
Q

LAMA adverse effects

A

dry mouth, dizziness, blurred vision, upper RI, and paradoxical bronchospasms

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22
Q

Turdorza Pressair

A

LAMA
Aclidinium
DPI
Adult COPD only

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23
Q

Seebri Neohaler

A

LAMA
Glycopyrrolate
DPI, Nebulization soln
Adult COPD only

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24
Q

Yupelri

A

LAMA
Revefenacin
Nebulization solution
Adult COPD only

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25
Q

Spiriva

A

LAMA
Tiotropium
HandiHaler, Respimat
Handi- adult COPD
Respimate- 12yrs-adult

26
Q

Incruse Ellipta

A

LAMA
Umeclidinium
DPI
Adult COPD only

27
Q

ICS/LABA Clinical Pearls

A

LABA is recommended in combo with ICS. This assist with patient adherence

28
Q

Advair

A

ICS/LABA
Fluticasone/Salmeterol
DPI, HFA MDI
5yrs- adult

29
Q

AirDuo and AirDuo Digihaler

A

ICS/LABA
Fluticasone/Salmeterol
Respiclick (DPI)
Adult

30
Q

Symbicort

A

ICS/LABA
Budesonide/Formoterol
HFA MDI
5yrs-adult

31
Q

Dulera

A

ICS/LABA
Mometasone/Formoterol
MDI
Adult

32
Q

Breo Ellipta

A

ICS/LABA
Fluticasone/Vilanterol
DPI
Adult

33
Q

LABA/LAMA clinical pearls

A

*COPD only
*Not indicated for treatment of acute deteriorations

34
Q

Stiolto Respimat

A

LABA/LAMA
Olodaterol/Tiotropium
Respimate
Adult COPD only

35
Q

Anoro Ellipta

A

LABA/LAMA
Vilanterol/Umeclidinium
Ellipta
Adult COPD only

36
Q

Utibron Neohaler

A

LABA/LAMA
Indacaterol/Glycopyrronium
Neohaler
Adult COPD only

37
Q

Bevespi Aerosphere

A

LABA/LAMA
Formoterol/Glycopyrronium
Aerosphere
Adult COPD only

38
Q

Duaklir Pressair

A

LABA/LAMA
Formoterol/Aclidinium
DPI
Adult COPD only

39
Q

Trelegy Ellipta

A

LABA/LAMA/ICS
Fluticasone/Umeclidinium/Vilanterol
Ellipta
Adult- Asthma/COPD

40
Q

Breztri Aerosphere

A

LABA/LAMA/ICS
Budesonide/Glycopyrrolate/Formoterol Fumarate
Aerosphere
Adult COPD only

41
Q

Intal

A

Mast cell stabilizer
Cromolyn
Nebulizer solution
2yrs-adult

42
Q

Mast cell stabilizer Adverse Effects

A

High incidence of unpleasant taste, rare cardiac arrhythmias, coughing, dyspnea, sore throat

43
Q

Mast cell stabilizer clinical pearls

A

*Less effective than low-dose ICS
*Prevents increase in bronchial hyperreactivity seen in allergy season

44
Q

Leukotriene modifiers adverse effects

A

Neuropsychiatric events, Churg-Strauss Syndrom, increased hepatic transaminases

45
Q

Leukotriene modifiers clinical pearls

A

*Less effective than low dose ICS and ICS/LABA in asthma
*Have not be adequately trialed in COPD

46
Q

Singulair

A

Leukotriene Modifiers
Montelukast
Tablets (chewable), granule packets
1 yr-adult

47
Q

Accolate

A

Leukotriene Modifiers
Zafirlukast
Tablets
5 yrs-adult

48
Q

Zyflo CR

A

Leukotriene Modifiers
Zileuton
IR, ER tablets
Adult

49
Q

Bronchodilation through inhibition of PDE III and PDE IV

A

Methylxanthines

50
Q

Methylxanthines adverse effects

A

insomnia, GI upset, hyperactivity, hypotension, tremor

51
Q

Theochron

A

Methylxanthines
Theophylline
ER 12, 24 hr tablets
ER 24 hr capsules
Liquid

52
Q

Inhibits binding to receptors on mast cells and basophils, inhibit mediator release and attenuation of early- and late-phase allergic response

A

Anti-IgE

53
Q

Xolair

A

Anti-IgE
Omalizumab
Syringe with reconstitution
6yrs-adult

54
Q

Anti-IgE adverse effects

A

headache, injection site reaction, arthralgias, thrombocytopenia, pharyngitis, sinusitis, upper RT infection

55
Q

Anti-IgE clinical pearls

A

*Do not give more than 150mg per injection site
*Monitor for anaphylaxis before and after injection
*Approved for mod-severe asthma in patients w inadequately controlled use of ICS

56
Q

Blocks binding to the alpha chain of the IL-5 receptor complex, which results in reduced production and survival of eosinophils

A

Anti-IL5

57
Q

Nucala

A

Anti-IL5
Mepolizumab
Injection
6yrs-adult

58
Q

Cinqair

A

Anti-IL5
Reslizumab
Solution for injection
Adult

59
Q

Fasenra

A

Anti-IL5
Benralizumab
Auto inject or prefilled syringe
adult

60
Q

Blocks binding to reduce eosinophil trafficking and IgE reactions while also blocking IL-13 to reduce mucus secretion and airway remodeling

A

Anti-IL4/IL13

61
Q

Dupixent

A

Anti-IL4/IL13
Dupilumab
Injection
Adult

62
Q

Daliresp

A

Phosphodiaesterase-4 Inhibitors
Roflumilast
Tablets
Adult- COPD only

Therapeutics (16 decks)

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