Hypothyroidism Flashcards
General features
Weight […]
[…]
Cold intolerance
General features
Weight gain
Lethargy
Cold intolerance
Skin features
[…] (anhydrosis), cold, yellowish skin
Non-pitting […] (e.g. hands, face)
Dry, coarse […] hair, loss of […] aspect of eyebrows
Skin features
Dry (anhydrosis), cold, yellowish skin
Non-pitting oedema (e.g. hands, face)
Dry, coarse scalp hair, loss of lateral aspect of eyebrows
GI feature
constipation
Gynaecological feature
Menorrhagia
Neurological
Decreased deep tendon reflexes
Carpal tunnel syndrome
Epidemiology
More common in women than in men
Primary hypothyroidism causes
- […] thyroiditis
- most common cause
- […] disease, associated with […], […] or pernicious anaemia
- may cause transient thyrotoxicosis in the […] phase - […] thyroiditis (de […])
- […] thyroiditis
- After […] or […] treatment
- Drug therapy (e.g. […], amiodarone or anti-thyroid drugs such as […])
- Dietary […] deficiency
Hashimoto’s thyroiditis
most common cause
autoimmune disease, associated with IDDM, Addison’s or pernicious anaemia
may cause transient thyrotoxicosis in the acute phase
5-10 times more common in women
Subacute thyroiditis (de Quervain’s)
Riedel thyroiditis
After thyroidectomy or radioiodine treatment
Drug therapy (e.g. lithium, amiodarone or anti-thyroid drugs such as carbimazole)
Dietary iodine deficiency
Mx
Levothyroxine
Side-effects of thyroxine therapy
- […]: due to over treatment
- reduced […] […] […]
- worsening of […]
-[…][…]
Side-effects of thyroxine therapy
hyperthyroidism: due to over treatment
reduced bone mineral density
worsening of angina
atrial fibrillation
Interactions of levothyroxine
[…], […] carbonate
- absorption of levothyroxine reduced, give at least 4 hours apart
Interactions of levothyroxine
iron, calcium carbonate
absorption of levothyroxine reduced, give at least 4 hours apart
