Acute Respiratory- Adults Flashcards

1
Q

acute bronchitis

A
  • Acute bronchitis is a lower respiratory tract infection involving the large airways (bronchi), without evidence of pneumonia, that occurs in the absence of chronic obstructive pulmonary disease.
  • Self-limited inflammation of the bronchial respiratory mucosa leading to productive or non-productive cough
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2
Q

acute bronchitis: s/s

A

o Cough persisting > 5 days
o Dry or Productive
o May last several weeks
o +/- wheezes, rhonchi (will clear with cough)
o Fever/systemic symptoms typically absent
o Chest wall tenderness from coughing is common
o Often preceded by URI symptoms

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3
Q

acute bronchitis: diagnostics

A

o Based on hx and PE
o Focus should be on ruling out more serious illness
o CXR indicated only when clinical features suggest pneumonia

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4
Q

acute bronchitis: differentials

A

o Pneumonia, COVID, Influenza, etc.
o Postnasal drip/upper airway cough syndrome
o GERD
o Asthma
o COPD
o ACEI use
o Heart Failure
o PE
o Lung Cancer

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5
Q

tx for symptomatic acute bronchitis

A

o Cough suppressants:
* Dextromethorphan
* Guaifenesin
* Honey
* Codeine
o Humidification
oAntihistamine/Decongestants/Analgesics – if associated URI symptoms or muscle pain from cough
o Inhaled beta-agonists: Albuterol
* If wheezing or underlying lung disease
o Antibiotics are generally NOT indicated

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6
Q

acute bronchitis: pt education

A

o A nagging cough can last for several weeks
o Antibiotics are not indicated for acute bronchitis
o **You should follow-up in the office if you develop:
* A fever higher than 100.4°F (38°C)
* Chest pain when you cough, trouble breathing, or coughing up blood
* New discolored mucus (getting progressively darker)
* A barking cough that makes it hard to talk
* A cough and weight loss that you cannot explain

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7
Q
  • Pneumonia is unlikely if all of the following are absent:
A
  • fever >/ 100.4
  • tachypnea >/ 24
  • tachycardia >/100
  • evidence of consolidation on chest exam: rales, egophony, fremitus
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8
Q

pertussis “whooping cough”

A

highly contagious

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9
Q

pertussis presentation

A

o Stage 1: Catarrhal period 1-2 weeks
* Nonspecific malaise, rhinorrhea and mild cough
* Excessive lacrimation and conjunctival injection are usually present
o Stage 2: Paroxysmal coughing fits that can last 2-3 months
* Characteristic “whoop” or barking cough
* Post-tussive syncope or emesis often present
* Otherwise feel well
o Stage 3: Convalescent; less persistent cough lasts 1-2 weeks

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10
Q

pertussis clinical criteria for testing

A

o Cough lasting >/= 2 weeks, without a more likely diagnosis and at least 1 of the following:
* Paroxysms of coughing
* Inspiratory whoop
* Posttussive vomiting

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11
Q

diagnosis pertussis

A

choice of testing depends on duration of cough
* culture (nasal swab or aspiration): gold standard
* PCR (nasal swab or aspiration)
* serology

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12
Q

tx of pertussis

A

o 1st line: Macrolide antibiotics (azithro or clarithromycin)
o 2nd line: Bactrim
o Close contacts should also be treated regardless of immunization history
o Abx treatment does not necessarily improve cough symptoms but reduces transmission to others

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13
Q

complications of pertussis

A

o Super-Infection (Pneumonia)
o Mechanical r/t severe cough (abd hernia, subconjunctival hemorrhage, rib fractures)
o Morbidity and mortality most common in infants and young children
o Adults can experience significant time away from work/school, social isolation, sleep deprivation, anxiety

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14
Q

pertussis prevention–vaccination

A
  • Tdap: tetanus booster + reduced dose of diphtheria and pertussis approved for age 11-64
    1 dose between 11 and 18
    1 booster dose between 19 and 64
  • Adults > 64 who have not previously received Tdap should receive a single booster
  • Pregnant women should receive a Tdap booster btwn 27 and 36 weeks during every pregnancy
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15
Q

pneumonia

A
  • Infection of the lower respiratory tract classified by how it is acquired
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16
Q

pneumonia etiology

A

o Typical bacteria: Streptococcus pneumoniae (60-70%) (although incidence is decreasing), Haemophilus influenzae, and Moraxella catarrhalis
o Atypical bacteria: Legionella pneumophila, Mycoplasma pneumoniae, and Chlamydophila pneumoniae
o Viruses: Influenza, rhinovirus, adenovirus, COVID-19

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17
Q

pneumonia risk factors

A

o Older age (>65)
o Smoking
o Alcohol use >80 gm/d (> 5 drinks)
o Comorbidities (COPD/lung disease, CHF, DM, malnutrition, stroke, immunocompromise)
o Viral respiratory infection
o Crowded living conditions

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18
Q

presentation pneumonia

A

loof for fever, chills, rigors, cough, malaise

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19
Q

presentation pneumonia typical

A
  • age <5 or >40
  • onset: abrupt
  • cough: productive
  • sputum: rusty/purulent
  • rigors: often present
  • fevers > 39 C
    consolidation: present
    leukocytosis: 15+, shift
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20
Q

presentation pneumonia: atypical

A
  • age: <40
  • onset: gradual
  • cough: paroxysmal, non-productive
  • sputum: minimal, mucoid
  • rigors: absent
  • fevers <39 C
  • consolidation: often absent
  • leukocytosis: often absent
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21
Q

pneumonia diagnosis

A

o Physical Exam:
* Full HEENT, respiratory exam, cardiac exam
* Significant findings: rales (unilateral= bacterial; bilateral= atypical) that do not clear with cough, bronchial breath sounds, dullness to percussion, egophony (E to A changes)
* Imaging:
* CXR (A/P plus lateral): can be normal in early disease, may show infiltrative changes

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22
Q

pt teaching pneumonia

A

o Clear directions for antibiotic use
o Follow up in 24 to 48 hours by phone or in person
o Push fluids by mouth
o Use antipyretics prn fever & myalgias
o If constant non-productive cough, try codeine, esp. qhs

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23
Q

tx pneumonias

A

o IDSA guidelines: monotherapy with Amoxicillin, Doxycycline, or Macrolide if there are risk factors for MRSA, pseudomonas, or comorbidities
o Duration of Treatment
* Outpatient: generally 5 days

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24
Q

follow-up pneumonia

A

o Clinical follow-up 24-48 hours after initiation of treatment is appropriate
* Assess VS, mentation, appetite

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25
Q

referral to hospitalization: pneumonia

A

o CURB-65 Calculator– Confusion, Uremia >7, RR >/ 30, BP <90/<60, Age>/65
o Pneumonia Severity Index (PSI) Calculator

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26
Q

pneumonia prevention

A

o Smoking cessation
o Influenza vaccination
o Pneumococcal vaccination for at risk patients
o Ongoing infection control measures

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27
Q

pneumonia vaccination

A

PCV20 - Pneumococcal polysaccharide vaccine
* average risk adults >/ 65- one dose
PPSV23
* recommended for adults >/ 65 and persons 19-64 with DM, ETOH, liver disease, cigarette smoker, chronic heart disease
PCV7/13/15/20
* childhood series, adults >/65, adults with immunocompromise, asplenia, CSF leak, cochlear implant, advanced kidney disease

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28
Q

infiltrative changes: typical pneumonia

A

unilateral: only one side of the lobe is inflamed and will be seen on imaging

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29
Q

infiltrative changes: atypical pneumonia

A

bilateral– both lower lobes are severely inflammed and will see on imaging

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30
Q

COVID-19: s/s

A

o Cough
o Fever
o Myalgias
o Headache
o Dyspnea
o Sore throat
o Diarrhea
o N/V
o Chest pain
o Anosmia or other smell abnormalities
o Agnosia or other taste abnormalities
o Rhinorrhea and/or nasal congestion
o Confusion

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31
Q

testing for COVID-19

A

o Symptoms= test immediately
o Exposed to COVID-19 w/o sx, wait at least 5 full days before testing. Too early = false negative
o If you are in certain high-risk settings*, routine testing programs.
o Consider testing before contact with someone at high-risk for severe COVID-19, especially if you are in an area with a medium or high COVID-19 Community Level.
o **High-risk settings: congregate living, prisons, LTC, hospitals

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32
Q

diagnosis: COVID-19

A

gold standard: PCR, NAAT

33
Q

risk for severe COVID-19

A
  • age >/ 65 years
  • asthma
  • cancer
  • heart conditions
  • smoking
  • diabetes
  • chronic lung disease
  • physical inactivity
  • pregnancy or recent pregnancy
  • substance use disorders
34
Q

who to treat: COVID-19

A

acute illness and at least 1 of the following:
* > 64 yrs old
* immunosuppression
* risk factors for severe COVID-19
* >49 years old and unvaccinated

35
Q

what to treat with: COVID-19

A
  • Nirmatrelvir-ritonavir (Paxlovid)
  • Molnupiravir
  • Remdesivir
36
Q

Nirmatrelvir-ritonavir (paxlovid)

A
  • Protease inhibitor (not unlike those used for HIV treatment)
  • Must be started by 5th day from start of symptoms
  • Generally, very well tolerated
37
Q

Nirmatrelvir-ritonavir (Paxlovid): contraindications/precautions

A

o Contraindicated:
* Anti-arrhythmics (flecainide, amiodarone)
* Anti-psychotics (clozapine, lurasidone)
* Anti-seizure (phenytoin, phenobarbital, carbamazepine)
o Hold or adjust:
* Statins (esp. lova- simva-)

38
Q

Nirmatrelvir-ritonavir (Paxlovid): side effect

A

covid rebound
o Mild sx returning after completion of antiviral course (24-48hrs)
o Rare progression to severe symptoms
o If sx recur, recommend antigen retesting and extend isolation if positive.

39
Q

pt teaching: COVID-19

A
  • Clear directions for antiviral use
  • Follow up in 24 to 48 hours
  • Push fluids by mouth
  • Use antipyretic to control fever & myalgias as needed
  • OTC cough suppressants, codeine may be appropriate
  • Isolation:
    o Isolate 5 day from start of symptoms
    o Continue to wear mask for additional 5 days.
    o If “rebound” and antigen is positive, isolate for additional 2 days, then retest
    o Repeat testing not generally recommended
40
Q

long COVID s/s

A
  • fatigue
  • dyspnea
  • chest discomfort
  • cough
  • anosmia (loss of smell)
41
Q

covid-19 prevention

A
  • 6 ft distance
  • Wear masks
  • Do not touch mouth, eyes, nose,
  • Stay at home if you are sick
  • Clean and disinfect surfaces
  • Hand hygiene
42
Q

COVID-19 vaccination

A

Who:
o Everyone older than 6 months
o Adults and children same frequency, different dosing
* Immunocompromised – different recommendations

Moving toward annual boosters
o Flu-COVID combos

43
Q

upper respiratory infection (“common cold”)

A

A self-limited viral illness of the upper respiratory structures

44
Q

URI: common pathogens

A

o Rhinovirus (most common)
o Coronavirus
o Parainfluenza, adenovirus, enterovirus, RSV (more common in kids), & influenza

45
Q

URI: modes of transmission

A

o Hand contact
o Direct contact with an infected person or indirect contact with a contaminated environmental surface
o Small particle droplets: Airborne from sneezing or coughing
o Large particle droplets: Requires close contact with an infected person
o Cold-inducing viruses are viable on human skin and fomites for 2+ hours

46
Q

URI: infectivitiy

A

o Peak viral shedding is on the second and third day of illness
o Low levels of viral shedding may persist for up to two weeks
o 24-72 hour incubation period
o Typical duration of illness is 3-10 days but can last up to two weeks
o Smokers are more likely to experience prolonged symptom duration

47
Q

URI: risk factors

A

o Exposure to children in daycare, psychological stress, poor sleep

48
Q

URI: risk for increased severity

A

o Smoking, chronic illness, immunodeficiency, malnutrition

49
Q

s/s of URI

A

o Rhinitis
o Nasal congestion: Clear and/or purulent discharge
o Sore throat: Often described as “scratchy” or “dry”
o Cough: Often begins a day or 2 after nasal symptoms
o Malaise
o Fever uncommon in adults but may occur in children
o Don’t judge your mucus by its color!

50
Q

diagnosis of URI

A

o PE is typically largely unremarkable
o No diagnostic tests are routinely indicated

51
Q

physical exam findings: URI

A

o Eyes: possible conjunctival injection
o Nasal mucosal swelling; nasal congestion
o Pharyngeal erythema
o Adenopathy: usually absent, or minimal
o Lung exam: Usually clear unless secondary bronchospasm; e.g. wheezing

52
Q

tx of URI

A

o Treatment is supportive/symptomatic!
o Remember: Typically, self-limiting
Rhinorrhea:
* Intranasal cromolyn sodium (OTC NasalCrom) or ipratropium
* Combination decongestants (pseudoephederine) and antihistamines (loratadine, fexofenadine, cetirizine, diphenhydramine)
o Combination treatment thought to be more effective than either agent alone; antihistamines not helpful alon
* Fever/Sore Throat/Headache/Malaise:
o Analgesics/Antipyretics: acetaminophen, ibuprofen
* Cough:
o Antitussives (dextromethorphan) and expectorants (guaifenesin) shown to have marginal benefit at best; for mild symptoms, would not use

53
Q

pt education on URI

A

o Review expected course and duration
o Discuss symptomatic treatment and prevention of transmission (hand hygiene)
o Provide reassurance that antibiotics are not needed and may have side effects
o Follow-up in the office if they develop:
* Persistent fever >100.5
* Shortness of breath
* Persistent dark colored secretions

54
Q

Acute Rhinosinusitis (ARS)

A
  • Symptomatic inflammation of the nasal cavity and paranasal sinuses lasting less than four weeks
55
Q

common pathogens of acute rhinosinusitis

A

o Most common pathogens: rhinovirus, influenza, parainfluenza

56
Q

Tx for acute rhinosinusitis

A
  • Patients with acute viral rhinosinusitis (AVRS) should be managed with supportive care. There are no treatments to shorten the clinical course of the disease.
57
Q

s/s acute rhinosinusitis

A

o Nasal congestion/post-nasal drip
o Halitosis (bad breath)
o Headache
o Referred dental pain
o Fever
o Ear fullness/otalgia
o Hyposmia/anosmia (decreased sense of smell or no sense of smell at all)
o May have sore throat, cough, nausea (often associated w/ post-nasal drip)

58
Q

physical exam: acute rhinosinusitis

A

o Assessment of vital signs, eyes, ears, pharynx, teeth, sinuses, lymph nodes, and chest
o After vitals, start with eyes
o Tenderness to palpation over the sinuses
o Anterior rhinoscopy: mucosal edema & erythema, inferior turbinate hypertrophy, and rhinorrhea or purulent discharge
o Post-nasal drip, cobblestoning (can see this in allergic conditions as well)
o Good to also look at teeth, esp. if pt reports tooth pain. Use a tongue depressor to tap the teeth.
o Role of Imaging: when indicated, CT without contrast

59
Q

diagnosis: acute rhinosinusitis

A

o Generally based on H&P
o Do not rely on sinus palpation to assist w/ dx
o For chronic symptoms or treatment failure consider:
o CT scan w/o contrast (gold standard)
o ENT referral
o X-rays: low sensitivity/specificity
o MRI: Not usually advised (tend to “overread”)

60
Q

tx of acute rhinosinusitis

A

first line: OTC analgesics and antipyretics, saline irrigation, intranasal glucocorticoids

61
Q

acute bacterial rhinosinusitis: s/s

A
  • Persistent symptoms of ABRS lasting >10 days
    o Specifically fever, purulent discharge, facial/dental pain
    o Symptoms of a typical viral upper respiratory infection that are slowly improving but then worsen again with more severe symptoms and signs (new-onset fever, headache, nasal discharge) after five to six days
  • ”double worsening” or “double sickening”

o Onset of severe symptoms (high fever->102°F, purulent nasal discharge or facial pain) for at least 3-4 consecutive days at the beginning of illness

62
Q

Acute Bacterial Rhinosinusitis (ABRS): risk factors

A

o chronic nasal congestion,
o asthma,
o cigarette smoking/exposure,
o anatomical abnormalities (polyps, deviated septum)

63
Q

Acute Bacterial Rhinosinusitis (ABRS): common pathogen

A

strep pneumoniae

64
Q

Acute Bacterial Rhinosinusitis (ABRS): complications

A

o orbital/periorbital cellulitis,
o osteomyelitis,
o sinus thrombus,
o intracranial/epidural abscess
o meningitis

65
Q

Acute Bacterial Rhinosinusitis (ABRS): tx

A

o Many patients with ABRS have self-limited disease that resolves without antibiotic therapy!
o Amox/clavulanate aka Augmentin
o Amoxicillin
* Due to antibiotic resistance you will often see Augmentin as 1st line, but Amoxicillin also used
* For PCN allergy, doxycycline or third generation cephalosporin with or without clindamycin (due to resistance)
* Duration of therapy: 5-7 days usually enough unless severe; more SE with 10 day treatment courses

66
Q

risk factors for resistance

A

o Age >/= 65
o Hospitalization in the last 5 days
o Antibiotic use in the previous month
o Immunocompromise
o Multiple comorbidities
o Severe infection
o **1st line treatment in high risk patients: High dose Augmentin (2gm PO bid)

67
Q

indications for urgent referral

A

o Persistent high fevers
o Abnormal vision/EOM
o Change in mental status
o Periorbital edema
o Cranial nerve palsies
o Meningeal signs

68
Q

influenza

A

acute respiratory infectio, a self-limiting virus

69
Q

infleunza A

A

Affects multiple species, including:
o Humans
o Swine
o Equine
o Birds

70
Q

influenza A transmission/incubation

A

o Large droplet transmission:
* Inhalation of resp particles (cough, sneeze)
o Small particle transmission:
* Talking, exhalation
o Fomite
o Virus detectable & may shed in resp secretions up to 24 hours BEFORE sx onset
o Incubation:
* 24-48 hours

71
Q

s/s influenza A

A

o Abrupt onset!
o Fever, chills, myalgias
o Malaise, anorexia
o Headache
o Cough (dry)
o Nasal congestion (clear)
o Sore throat
o Fever 100-104℉
o Convalescent phase: 1-2 weeks after acute febrile stage
* Cough, malaise, fatigue
o Some people can have mild illness like a cold

Children:
* Irritability, refusal to eat, rhinitis, GI sx like v/d

Older adults:
* Less likely to have those classic flus sx like younger individuals, may not have fever, anorexia, malaise, dizziness;
* Higher morbidity/mortality

72
Q

influenza A: H & PE

A

o Diagnosis largely rests on history
o Focused PE:
* General survey, HEENT, cardiac, pulmonary
o Clinical findings that may be present:
* Fever likely
* Skin: Hot/moist, flushed face
* May have enlarged, tender cervical LN
* Lungs typically clear

73
Q

diagnostics influenza

A

RT-PCR (most sensitive/specific) stick up the nose
* Yields rapid results
* Differentiates between influenza types/subtypes

Rapid flu tests:
* Distinguishes between A&B; <30 min results
* Lower sensitivity than RT-PCR

When should we test?
* If the result will influence management decisions
* However, testing should not delay initiation of treatment, if indicated

74
Q

tx for influenza

A

supportive therapy
* analgesics
* cough suppressants
* decongestants
* antihistamines
* local anesthetics

Antivirals
* most commonly used: Oseltamivir (Tamiflu)

75
Q

who should receive antiviral tx?

A
  • persons who are hospitalized
  • persons who have severe, complicated or progressive illness
  • other persons who are at high risk includng:
  • persons <2 and >65
  • persons with chrominc pulmonary (including asthma), cardiovascular, renal, hepatic, hematological, metabolic, or neurologic
  • persons with immunosuppression
  • persons who are pregnant or postpartum
  • persons aged younger than 19 years who are receiving long-term aspirin therapy
  • native americans/alaskian natives
  • persons who have a BMI >/ 40
  • residents of nursing homes and other chronic care facilities
76
Q

influenza prevention

A

All persons 6 months and older should be vaccinated annually, ideally by October

77
Q

influenza vaccine

A

The first time a child between ages 6 months and 8 years receives the flu vaccine TWO doses are required at least 4 weeks apart (cdc.gov)

78
Q

URI vs influenza

A

URI
* no fever
* no headache
* general aches and pains is sometimes, mild
* fatigue and weakness is sometimes, mild
* no extreme fatigue
* runny nose
* sore throat
* sneezing
* cough
* chest dicomfort is sometimes, mild
* onset gradudal

influenza
* fever
* headache
* general aches and pain
* fatigue and weakness
* extreme fatigue
* runny, stuffy nose
* sneezing
* chest discomfort
* sudden onset
* can lead to pneumonia and respiratory failure

79
Q

chemoprophylaxis

A
  • Long term care facility – outbreaks; 2 lab confirmed cases within 72 hours in residents on the same unit
  • Chemoprophylaxis is recommended for all asymptomatic patients, and consider for certain staff, especially unvaccinated and recently vaccinated persons