Lecture 6-9 Flashcards

1
Q

What is biological evolution?

A

Gradual change in the inherited traits of a population.

Survival: maintain internal homeostasis, respond to external stimuli, consume and produce energy
Reproduction: reproduce and have a form of heredity

Survival + reproduction = natural selection

Change in allele frequencies in a pop. over time
Driven by variation in reproductive success (fitness)

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2
Q

What is the Darwinian Revolution?

A

Publiction of “On the Origin of Species”
1) The tree of life: all species on Earth have evolved from other species (perhaps, ultimately, from just one)

2) Natural Selection: organisms are well-adapted to their environments because they accumulate, over the generations, traits that enable them to survive and/or reproduce better than organisms lacking those traits

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3
Q

What is natural selection?

A

Individuals in a pop. differ in their traits

Some traits confer an advantage (in a given environment)
- by that advantage, those traits allow certain individuals to survive and reproduce more

Individuals that have these traits survive and reproduce better than others
- i.e. selection is on phenotype (expression of trait)

If differences are heritable, the frequency of advantageous traits will increase in the next generation
- i.e. evolution is due to changing “genotype” (genetic coding for traits)

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4
Q

Gene definition

A

A self replicating DNA unit that occupies a specific location on a chromosome and determines a particular characteristic in an organism

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5
Q

Allele definition

A

A variant (different) form of a given gene (section of DNA) that codes for smt (e.g. a trait)

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6
Q

What is fitness in terms of biological evolution?

A

Fitness translates to reproductive success

I.e. how many surviving offspring does one have compared to others in the pop.

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7
Q

What is a phenotype?

A

Interaction between genotype and environment
Even individuals with the same genotype have different expressions depending on the environment (plasticity)

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8
Q

Why do individuals’ genetics vary?

A

mutuation
mode of reproduction

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9
Q

How do prokaryotes transfer info from generation to generation?

A

An enzyme gently break apart fhe two DNA strands
Other enzymes attach complementary bases to each of the old strands
Another enzyme checks for mistakes (proof-reading) and a DNA repair enzyme fixes them

Result: two strands virtually identical to the original

Mutation: mistakes happen! inital source of all variation

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10
Q

What is the reproduction in prokaryotes?

A

Binary fission
Replication of the circular chromosome followed by fissioning of the cell
Transmission of DNA-coded info across generations

DNA replication: cell fission (splitting) placing replicated DNA into daughter cells

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11
Q

What is binary fission?

A

Asexual reproduction in prokaryotes, creates new prokaryotes and some genetic diversity via mutation (identical apart from mutations)

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12
Q

What are some other ways prokaryotes transmit genetic info (not equal to reproduction)?

A

All do not = reproduction, but introduces genetic variation

Conjugation: sharing plasmids (separate ring of DNA)

Transformation: a prokaryote picks up a plasmid (genetic material) from the environment

Transduction: a virus relocates DNA from one prokaryote to another via viral replication cycles

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13
Q

What is different about the genetic structures of eukaryote cells?

A

Genetic material organized into multiple linear chromosomes

Each chromosomes consists of one long molecule of DNA

After DNA replication, two identical “sister chromatids” form

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14
Q

What is mitosis?

A

Duplicate chromosomes lines up and are pulled to opposite sides of parent cell
The cell then divides (fission) to produce daughter cells

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15
Q

What are the steps of asexual reproduction in a single-celled eukaryote?

A

Start off with a haploid (N) cells - 3 chromosomes
Duplication: chromosomes and DNA duplicate
Mitosis/fission: results in two identical haploid (N) cells with 3 chromosomes

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16
Q

What are the steps of sexual reproduction?

A

Gametes: 2 haploid (N) cells, each with 3 chromosomes but from different mating strains (2 parents)

Gametes fuse to form diploid (2N) zygote

6 chromosomes become uncondensed inside the new nuclear membrane

Meiosis: we start off with a diploid (2N) zygote

Reassortment or reassortment + recombination: Chromosomes duplicate, and homologous chromosomes line up in center of cell (random process )

Reassortment: homologous chromosomes separate and move to opposite sides of cell
2 groups of 3 chromosomes (each with replicated sister chromatids)

Sister chromatids separate
Now 4 groups of 3 chromosomes each

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17
Q

What creates more possible combinations in gametes during reassortment?

A

More chromosomes

Example:
N=2 –> 4 possible gametes
N=3 –> 8 possible gametes
N=4 –> 16 possible gametes

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18
Q

What are the benefits of sexual reproduction compared to asexual reproduction?

A

Generates a lot of variation

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19
Q

What are the consequences of sexual reproduction?

A

Mate searching costs
- as pop. size grows smaller, probability to find a mate decreases –> can lead to extinctions

Competition

Display costs

Only half of pop. generates offspring

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20
Q

What conditions favour sexual reproduction?

A

High number of environmental factors (complex)

high genes per trait

Low background mortality

Strong soft selection

Low mutation rate

Periodic catastrophes

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21
Q

What is hard selection?

A

Extra mortality (reduced reproduction) for maladapted individuals

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22
Q

What is soft selection?

A

No extra mortality, but who dies depends on fitness of other individuals

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23
Q

What are direct advantages of sex?

A

DNA repair mechanism
Masking mutations – higher chance that one copy works

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24
Q

What is the biochemical evidence for Archean ancestor to eukaryotes?

A

DNA sequence data from genes in the nucleus of eukaryotes suggests that eukaryotes are more closely related to Archeae than to bacteria

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25
Q

What is the biochemical evidence for bacterial ancestor to eukaryotes?

A

Mitochondria and chloroplasts (eukaryote organelles) have their own circular DNA and prokaryoteic-type ribosomes. Most similar to bacteria

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26
Q

What is endocytosis?

A

A substance gains entry into a eukaryotic cell; the cell membrane wraps itself around the particle and pinches off a vescicle inside the cell

Steps:
- Food particle taken in by endocytosis
- Fusion forms secondary lysosome
- Food particles digested
- Products of digestion
- Exocytosis of waste

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27
Q

Is simple observation and measurement sufficient to assess descent using comparisons involving phenotypic traits?

A

No, it does not account for environmental influence on phenotpes, ontogenetic changes, identification of “derived” traits. There is also insufficient data from living and fossil organisms to unambiguously trace changes in time as well as a lack of universal traits.

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28
Q

What needs to happen to have the chance of finding a fossil?

A

Chance of dying in one piece, being fossilized, remaining undisturbed, being exposed, being found, and being recognized.

The probability of all of these events occurring is extremely small.

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29
Q

What are the advantages of assessing descent through comparisons involving molecular traits?

A

Nucleotide sequences provide a direct record of all info stored in the genome.

No environmental or ontogenetic effects on the observed traits

Potential for universal traits

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30
Q

What are the disadvantages of assessing descent through comparisons involving molecular traits?

A

Traits observed only with use of sophisticated technology.

Inferring patterns of change in time not intuitive.

Back mutation at a site in the sequence is possible and complicates analysis.

Assuming constant molecular clock.

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31
Q

What are the steps to reconstructing phylogeny (lines of descent)?

A

1) Acquire nucleotide sequence data
- sampled part of a genome depends on how far back in time the relationships of interest lie

2) Align sequences from different organisms
- allow for mismatches due to point mutations, insertions, and deletions

3) Reconstruct most likely lines of descent
- assess the minimal number of steps requires to change from one sequence to another and use this as a measure of relatedness across all the organisms in the analysis

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32
Q

What are Acritarchs?

A

Early marine plankton.

A group of eukaryote fossils probably including algae, ciliates, dinoflagellates, radiolarians, foraminiferans.

Many acritarchs had tests (shells)
- example of structural complexity
- better source of fossil material

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33
Q

Why did diversity increase and what were the processes involved?

A

Increase in size of genome (more proteins, enzymes coded for)

Sexual reproduction (meiosis increases possible variation/mixing)

Increase in structural complexity (locomotion, protection)

Ecological changes (O2, energy sources, physical/biological landscape, photosynthesis in shallow water)

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34
Q

What are the origins of multicellular life?

A

Colonial protists and algae illustrate intermediate stage of complexity

Colonial life allows evolution of separate functions for individual cells
- feeding, reproduction, locomotion, etc.
- different metabolic pathways turned on and off

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35
Q

Ediacaran diversity

A

Variety of forms (vendian animals)
- leaflike fronds, round pads, worms

Some resemble jellyfish, sponges

Most are unique and unlike known animals

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36
Q

What was the ediacaran seascape in the late precambrian era (around 570 MA)?

A

Small shelly fossils in ocean sediments
Soft parts not preserved –> no idea what organism construced the shells

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37
Q

Burgess Shale Diversity

A

Ancestors of many modern groups
Arthropods, worms, sponges, jellyfish

But also many mystery organisms (failed lines of evolution? victims of chance?)

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38
Q

What is the Pikaia?

A

Ancestor of chordates, vertebrates, mammals and humans

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39
Q

What happened during the Cambrian Explosion?

A

Diversification in the animal kingdom
From Ediacarans (+/-570 MA) to early Cambrian animals (+/-540 MA)

All modern animal body plans established in less than 25 million years
Changes since then are just variations on those established plans

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40
Q

What is fitness landscape?

A

used to visualize the relationship between genotypes and reproductive success

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41
Q

What defined the Cambrian ecology?

A

Burrowing priapulid worms
Predators of small molluscs with spines
Swallowing prey all face the same way
Well-developed feeding behaviour

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42
Q

Give an example of a predator-prey “arms race”

A

Predator behaviour –> burrowing
Dig for prey –> hard sclerites
Jaws –> spines/completes shell
Modified hunting behaviour

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43
Q

Is there purpose in evolution?

A

No
Variations arise through chance mutations
Some mutations are positive, some negative, many neutral
Selection, not the organisms, decides which variations will survive of succees
Always interpret evolution in terms of chance variations, selection, probabilities of survival, not purpose and progress towards an objective

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44
Q

What does the predator-prey arms race mean in terms of evolution?

A

Interpret the sequence of events in the predator-pre arms race in the context of random mutations, variations and selection

Co-evolution

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45
Q

What can mutations create variations in?

A

Structure of the exoskeleton or skin, mouthparts, organs of locomotion, sensor structures

Behavioural traits

Physiological and metabolic pathways

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46
Q

What is co-evolution?

A

Selection of favourable mutations in a biotic interaction between different organisms

47
Q

Evaluate the predator-prey arms race through a random mutation lens

A

Predator behaviour
- scavengers randomly swallow live organisms - more nutrient
- some scavengers have mutations that allow digestion

Burrowing
- organisms with structural and behavioural that allow them to burrow in mud will not be encountered by scavengers

Dig for prey
- surface scavengers with longer legs penetrate deeper into the mud to find food - burrowing organisms are encountered

Hard sclerites
- burrowers with mutations that result in thicker skin may be harder to swallow - they will survive

–> many possible variations at each step in the process

48
Q

What are some putative mechanisms for explosion of diversity during the Cambrian?

A

Tectonic activity
CO2 degassing rate
Heating and melting of Snowball Earth
Increased photosynthesis
Increase pO2 50-75% during Ediacaran period/beginning of Cambrian
Enough to support energy requirements for larger predators

49
Q

What are some characteristics of the Proterozoic?

A

Photosynthesis evolved

Eukaryotes (cells with nucleus evolved)

Proliferation of bacterial mats

Great Oxygenation Event
- O began building up in the atmosphere
- Formed the ozone layer (filters out harmful UV radiation)

Near the end of the Proterozoic: multicellular photosynthesizers begin to appear (algae). Soft animals and hard bodied animals appear

50
Q

What are some characteristics of the Cambrian?

A

Shells and hard bodies start to dominate in the fossil record

Animals become more motile (predation)

Explosion of evolution of new body types in animals

The first chordate (animal with a long central nerve). The lineage that would go on to give rise to all vertebrates

51
Q

What are some characteristics of the Ordovician?

A

Mix of continents and shallow ocean shelves, rising and falling sea levels

First true vertebrates (fish with jaws) evolve from Pikaia

52
Q

What are some barriers to adapting to land?

A

Harmful UV radiation
Desiccation
Gas exchange
Buoyancy
Temperature fluctuations
Mineral nutrition
Reproduction
Vision and hearing

53
Q

How is harmful UV radiation a barrier ot adapting to land?

A

Water could filter UV light and protect light

Oxygen changed everything –> created an ozone shield which filters out enough UV radiation that life can survive on land

54
Q

How is desiccation a barrier ot adapting to land?

A

Aquatic organisms are adapted to being surrounded by water, dry out easily

Cannot be waterproof: need to allow for the passage of water and gases in and out of the body

Smaller organisms dry out faster
- greater surface area to volume ratio
- internal space = water storage
- surface area = water loss

55
Q

How is gas exchange a barrier ot adapting to land?

A

Gases (CO2 and O2) are absorbed differently depending on whether they are in air or dissolved in water
- need a new system of gas exchange

56
Q

How is buoyancy a barrier ot adapting to land?

A

Water and water pressure supports body tissues, air does not (for example, most of the weight of blue whales is supported by the environment around them)

Land plants and animals need supporting structures

57
Q

How are temperature fluctuations a barrier ot adapting to land?

A

Seawater: slow and little change (sea surface has changed as little as 4 degrees C over the past few centuries)

Land: quickl, large changes (as much as 30 degrees in 24 hours)

58
Q

How is mineral nutrition a barrier ot adapting to land?

A

Water contains dissolved minerals for added nutrition
Many aquatic animals are sessile (immobile) –> need a way to supplement on land

On land, nutrients are sometimes less concentrated and less accessible

59
Q

How is reproduction a barrier ot adapting to land?

A

Aquatic organisms need water to facilitate reproduction

Male and female gametes (egg and sperm) released into the water for fertilization and development (both animals and photosynthesizers)

60
Q

How is vision and hearing a barrier ot adapting to land?

A

Light and sound waves move differently through water compared to air –> needed to adjust vision and hearing

Evolved sense need modification before they can work in the atmosphere

61
Q

What are the traits of the first land colonizers?

A

From early cyanobacteria, green algae (eukaryotes, incl. mutli-cellular) appeared approx. 0.75 bya

Photosynthetic organisms tend to grow at the surface (get their energy from the sun). Wave action can throw organisms on shore, periodically exposing them to desiccation –> can still access nutrients in water, but still challenged to temporary life on land

Advantageous to grow near the surface (near light), in shallow waters, on coastal shelves

Selective force to tolerate desiccation

62
Q

What is the evolution of green algae?

A

Pop. of green algae exposed to periods of drought in the intertidal.
- selection for individuals which could tolerate extended periods of desiccation
- i.e. existing species had traits which likely predisposed them to being able to adapt to the terrestrial environment.

Over time, evolved from green algae to more complex forms that could survive entirely on land

Algae –> moss and liverwort (no vascular system)

63
Q

What is the evidence of the evolution of green algae into moss and liverwort?

A

Spores resembling modern liverwort spores found in Ordovician fossil record (no known species of aquatic liverworts)

Molecular clock of all modern plants –> work backwards to calculate the date when the began to diverge (use genetic info to build phylogenetic tree –> little difference in genetic code)

64
Q

How did plants adapt to desiccation on land?

A

Developed multiple cell layers and a layer of surface wax (the cuticle)

Evolved roots or tooth-like structure that direct movement of water into the body

65
Q

How did plants adapt to gas exchange?

A

Evolved specific pores (stomata) to allow for gas to enter
Could be closed to prevent the plant from drying out

66
Q

How did plants adapt to reproduction?

A

Evolved spores which could survive desiccation
- still depended on water to move them

Eventuall evolved seeds –> more desiccation-tolerant than spores (disperse genetic material)

67
Q

How did plants adapt to buoyancy?

A

Evolved strong fibers and compounds such as lignin and celluose for structural support

Big plants can have a skeleton

68
Q

How did plants adapt to temperature fluctuations?

A

Traits evolved to prevent desiccation eventually helped plants survive extreme temp. fluctuations
- much later, plants evolved methods (e.g. dormancy) to survive in extreme environments (deserts, winter)

69
Q

How did plants adapt to mineral nutrition?

A

Roots allowed plants to take minerals right out of the soil

Some plants formed symbiotic associations with microbes: exchange minerals for sugars

70
Q

Why did plants move on land before animals?

A

Plants are at the base of the food chain

71
Q

First animals on land

A

Multiple animal groups independently moved onto land

Cambrian era fossils show arthropod tracks on land even before plants. However, no permanent terrestrial species at this point. Footprints believed to have been made by animals fleeing predation in water

72
Q

Which animal group was the first group to move on land?

A

Arthropods: scorpions, millipedes, springtails all present in Devonian (410-360 MA)

Rapid increase in diversity after that time

73
Q

Which animal that moved onto land was our ancestor?

A

Tikaalik - Late Devonian (375 MA)
A lobe-finned fish
Shared ancestor of all tetrapods (amphibians, mammals, reptiles)
A transition fossil
Sturdy jointed arms for terrestrial support

Evolved to later form
- progressive evolution of limbs
- lived on land but still closely ties to water for reproduction

74
Q

Are lobe-finned fish extinct?

A

Though to be extinct, yet there are remnant populations

75
Q

Why could so many groups colonize land?

A

Structures that evolved for other uses are also effective for living on land
- e.g. exoskeleton of arthropods, verterbrate skeleton, types of movement

76
Q

How did animals adapt to desiccation on land?

A

Terrestrial animals have different mechanisms to prevent desiccation on land

Physical (waxy caoting on exoskeleton) –> arthropods

Scales –> reptiles

Behvarioural (live in damp habitats, active at night) –> amphibians

Concentrate waste, remove water and excrete waste as uric acid (drier, less water) –> reptiles

77
Q

How did animals adapt to gas exchange on land?

A

Must keep the membranes wet in dry air without losing water

Evolved lungs –> large surface area for gas exchange

Insects: small openings in exoskeleton (spriracles), network of tubes branching throughout bod (tracheae)
- limits the size of insects since there is not enough O to diffuse fast enough

Vertebrates: small opening (tracheae), sacs with large surface area and many blood vessels for gas exchange (lungs)

78
Q

How did animals adapt to reproduction on land?

A

Internal fertilization
- keep ova inside body to prevent desiccation
- fertilize inside female (prevents gametes from drying out)

Internal fertilization also maximizes the probability of gametes encountering one another

Terrestrial organisms are much more conservative –> internal fertilization makes it so that there is a higher chance that egg is fertilized

Zygote inside female –> need to get embryo outside
- modify egg for terrestrial life (self contained world, major energy investment by female)
- protects from desiccation, provides nutrients, gas exchange and waste disposal

79
Q

What is the amniotic egg?

A

Major evolutionary adaptation in reptiles
- allowed eggs to be laid on dry land

Temperature fluctuations still a problem
- bur in temperature-buffering material
- incubation behaviour

Fewer eggs produced
- need more resources per egg

Nesting parent is easy prey (vulnerable to predation)

80
Q

What is viviparity and what are the pros and cons of viviparity (live birth)?

A

Viviparity evolved multiple times in diverse groups. An internal egg is retained by the female after fertilization. Even fewer young that species with amniotic eggs

Pros: Increase parental investment is believed to allow for the increased survival of offspring

Cons: more parental investment (more energy)

81
Q

How did animals adapt to buoyancy on land?

A

Arthropods (e.g. insects): exoskeleton made of chitin

Molluscs: external shell (calcium), hydroskeleton (fluid pressure inside body)

Vertebrate (e.g. mammals): internal skeleton of cartilage and bone

82
Q

How did animals adapt to temperature fluctuations on land?

A

Homeothermy: the ability to regulate internal body temp.

Both active and passive strategies:

1) metabolism: Regulate own body temp. (constant internal body temp.), costly in terms of energy (must eat a lot)behavioural)

2) Poikilotherms: tolerate temp. (body temp. changes with external temp. –> reptiles)

83
Q

Homeotherms

A

Higher metabolism
Higher food requirement

84
Q

How did animals adapt to vision on land?

A

Sealed chamber filled with fluid (as opposed to early eyes that were filled with water from the environment)

85
Q

How did animals adapt to hearing on land?

A

Adaptations specialized in some species to airborne wavelengths
- cochlea in mammals still contains fluid for sound transmission

86
Q

What is the kingdom, phylum, class, order, family genus and species of humans?

A

Kingdom: Animalia
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: H. sapiens

87
Q

Who is our closest relative?

A

Chimpanzees, genus Pan

88
Q

How far back do we have to go in western scientific literature to recognize that humans and apes are related?

A

1735

89
Q

What were Lamarks suggestions?

A

First to suggest that apes and humans had a shared evolutionary history

Thought ancestral humans were likely tree dwelling, like apes today
- increasingly walked on the ground on two feet
- through acquired characteristics and over many generations, became bipedal and lost the ability to climb trees

90
Q

Why was there a lot of debate surrounding human evolutionary record?

A

We had only found a fraction of the fossil record that we have today.

Until the 1800s, no fossils found of ancient human species, only a few stone tools

91
Q

Why do the tropics not produce good fossils?

A

Things decay quickly (environmental conditions)

92
Q

What does the fossil record tell us about human evolution?

A

Based n many fossils from Kenya and around the Qorld, we now know there were many species of homo, starting 2-2.5 MYA

Our lineage split from what would become chimps around 5-13 MYA, with many intermediates

93
Q

Was hominid evolution a straight line (i.e. one species became another, all are our ancestors)?

A

Number of branch poitns that gave rise to more than one lineage
Lineages existed at the same time (different species of homo coexisted)
All of the lineages went extinct with the expections of homo-sapiens

94
Q

Australopithecus chacteristics

A

Bi-pedal, ape-like (Lucy)
Small brains, but some made and used tools
Change in diet
Greater sexual dimorphism
Habitat in Africa about 4.2-2 MYA

95
Q

Homo habilis characteristics

A

Brain is getting bigger, teeth smaller
Definitely made stone tools (the handyman)
Habitat in Africa about 2.4-1.5 MYA

96
Q

Homo erectus characteristics

A

Most successful human species identified to date
Believed to be the first to leave Africa
Big brains, tools, hunters
Fire, art, proto-speech?
Habitat in Africa, East and West Africa about 1.9 MYA to 150 000 years ago

97
Q

Homo antecessor characteristics

A

Sister species to H. sapiens
Suggests entire other lineage of human evolution
Habitat in Western and Southern Europe about 1.2 million-800 000 years ago

98
Q

Homo heidelbergensis characteristics

A

overlapped with (evolved from) H. erectus
New study 2020: shared Africa with H. sapiens
Habitat in Asia, Europe and northern Africa about 700 000-200 000 years ago

99
Q

Homo florensis characteristics

A

Species which live at the same time as our own
May have experienced insular dwarfism
Many primitive features
Habitat in Flores, Indonesia about 200 000?-50 000 years ago

100
Q

Homo neanderthalensis characteristics

A

Sister species to us (both evolved from a single common ancestor)
Had many technologies we recognize
Bred with Homo sapiens
Habitat in Europe and central Asia aobut 400 000-40 000 years ago

101
Q

Denisovans chracteristics

A

Another sister species to us
Believed descended from the same immediate common ancestor
No skull identified to date –> no official species name (not using the term homo)
The only human species identified solely by DNA

Habitat Western and Central Asia about 700 000-15-000 years ago

102
Q

Homo sapiens characteristics

A

Only extant species in the homo genus
Skull morphology has changed distinctly over time
Evolved in Africa nad left 185 000 years ago
Interacted with other homo species
Habitat originally Africa and now current global distribution about 300 000 years ago -today

103
Q

What drove human evolution?

A

Evolution associated with physical (e.g. bi-pedalism, larger brains) and technological (e.g. stone tools) changes that opened up new niches

Natural selection is driven by the fit between an organisms and its environment

The climate has changed around us over the last 2 MY
- climatic variability (temp. rainfall) and ecosystem changes
- favourable periods allowed expansion
- hominids adapted more climate extremes (seasonality, altitude)

104
Q

What is a roadblock in using morphological traits to evaluate evolution?

A

Difficult to distinguish chronospecies

Difficult to tell apart natural variations within species from differences separating species

105
Q

What is a roadblock in using DNA (molecular phylogeny) to evaluate evolution?

A

Half life of DNA is 521 years
Most recent extinction of other Homo likely H. neanderthalensis at 20 000+ years ago
We could not extract DNA to analyze –> widely believed we would never be able to analyze DNA past its half-life –> enter ancient aDNA

106
Q

What is ancient aDNA?

A

Current theoretical upper limit for analysis: 1.5 MY

PCR lets us amplify even very tiny samples. Then can build ancient genomes from fragments by comparing them to modern ancestors

107
Q

What are some drawbacks with ancient aDNA

A

Possibility of contamination

108
Q

What is the Neanderthal Genome Project

A

International effort to sequence entire genome of H. neanderthalensis from two bones

Used computer programs designed to eliminate bacterial DNA from sequence reads
- Resulting sequences were compared to modern H. sapiens DNA, and mapped by comparison to the modern human genome

109
Q

What were the discoveries from the Neanderthal Genome Project?

A

H. neanderthalensis likely started with a very small founder pop. of 3000 individuals

H. neanderthalensis had a gene mutation we believe to be required for complex speech

H. sapiens and H neanderthalensis hybridized and produced fertile offspring

110
Q

What did ancient aDNA uncover about the denisovans?

A

Only a finger bone and a few teeth

Denisovans interbred with H. sapiens and H neanderthalensis

As much as 17% of the genome of the Denivosan girl is from a Neanderthal genome

111
Q

What is eDNA?

A

DNA found in environments
DNA can be relatively stable especially when preserved in sediments (unlike RNA)

112
Q

What are the DNA kits we see nowadays?

A

DO not use complete genome analyses, but rather seqeunce a small subet of regions of interest

Many large-scale correlational analyses

Some traits have very simple genetic basis, example hair and eye colour

Characteristics such as height and freckles –> multiple genetic regions that can contribute to these traits

113
Q

Where is the greater proportion of deleterious mutations found?

A

In european populations (expected in a recent founder pop.)

114
Q

Where is the greater proportion of rare alleles found?

A

In african populations
Rare alleles are likely to be lost in founder populations, unless they become dominant