Adrenergic Antagonists

Question 1

Non selective α1 & α2 blocker (2 drugs)

Answer 1

Phentolamine , phenoxybenzamine

Question 2

Selective α1 antagonist ( 5 drugs)

Answer 2

(…Zosine)
1- Prazosin
2- doxazosine
3- terazosine
4- tamsulosine (very important)
5- alfuzosin

Question 3

Selective α2 blocker

Answer 3

Yohimbine

Question 4

DOC for pheochromocytoma

Answer 4

Phenoxybezamie ( α1&2 blocker)

Question 5

Treating Raynaud’s disease by

Answer 5

Phenoxybenzamine

Question 6

The Action of phentolamine& phenoxybezamine (3 points)

Answer 6

1. Prevent V.C of peripheral BV
2. Decreased peripheral resistance provokes tachycardia.
   3.block α2 in the heart ❤️ increases cardiac output.

Question 7

Indication of phentolamine (3 points)

Answer 7

1- diagnosis of pheochromocytoma
2- prevent dermal necrosis following extravasation of NE.
3- to treat hypertensive crisis.

Question 8

Indication of phenoxybenzamine (2 points)

Answer 8

1- to treat hypertension with patient with pheochromocytoma.
2- Raynaud’s disease.

Question 9

Adverse effects of phenoxybenzamine and phentolamine.(4 points)

Answer 9

1- Nasal congestion
2- inhibits ejaculation
3- miosis
4- reflex tachycardia.

Question 10

The action of Selective α1 blockers

Answer 10

V.D
~ reducing BP with less reflex tachycardia .( because it is selective)
~ cause minimal changes in cardiac output , renal blood flow .

Question 11

Therapeutic uses of selective α1 blockers ( zosin)

Answer 11

1- hypertension
2- hypertension with prostate enlargement
3- benign prostatic hyperplasia.(reduce urinary urgency.)

Question 12

Adverse effect of (..zosin)

Answer 12

First dose syncope
Nasal congestion
Orthostatic hypotension

Question 13

A selective α1A antagonist (2 drugs)

Answer 13

1- Tamsulosin ( very important)
2- alfuzosin

(α1A)receptor present in prostate and bladder neck.

Question 14

A drug used in (BPH) benign prostate hypertrophy & kidney stones is ( 2 drugs)

Answer 14

Tamsulosin , alfuzosin

Question 15

What is the therapeutic use of yohimbine

Answer 15

Used as aphrodisiac in the treatment of erectile dysfunction.

Question 16

What is the action of yohimbine

Answer 16

Increase sympathetic out flow to the periphery. By blocking α2 receptor.

Question 17

What is the adverse effects of α1 antagonists? ( 4 points)

Answer 17

1- orthostatic hypotension
2- Nasal congestion
3- inhibits ejaculation
4- reflex tachycardia.