13. Fenger

Question 1

structure of paramyxoviridae?

Answer 1

• SS RNA, nonsegmented
  helical + envelope
  RNA-dependent RNA polymerase

Question 2

pt presents w barking cough, name of cough?

virus causing? subtypes?

Answer 2

Parainfluenza (paramyxovirus)

Croup, ARD

Question 3

most important Ig for paramyxovirus immunity?

Answer 3

IgA

Question 4

1 cause of Lower RT infeciton in infants?

Answer 4

Pneumovirus/ RSV

Question 5

tx for RSV?

Answer 5

palivizumab

Question 6

function of F glycoproteins?

Answer 6

fusion and can make giant cells/syncytia/polykaryocytes

Question 7

funciton of H?

Answer 7

attachment

Question 8

function of N?

Answer 8

budding

Question 9

glycoproteins in parmyxovirus?

Answer 9

H, N and F

Question 10

glycoproteinsin morbilla virus?

Answer 10

H and F

Question 11

glycoproteins in pneumovirus?

Answer 11

F

Question 12

infection timeline for paramyxoviriday?

Answer 12

RSC, Parainfluenza 3, 1, 2, 4

Question 13

wc orthomyxoviridae protein is responsible for antigen shift?

Answer 13

H

Question 14

wt is contained in trivalent flu vaccine?

Answer 14

Type A
Type A
Type B

Question 15

wt is contained in quadravalent flu vaccine?

who would it be given to?

Answer 15

2 Type A
2 Type B

elderly or immune compromised

Question 16

MOA of amantadine and rimantadine?

Answer 16

inhibit uncoating

Question 17

MOA of Zanamivir and oseltamivir?

Answer 17

inhibits neuroamidase

Question 18

MOA of ribavirin?

Answer 18

inhibits RNA synthesis

Question 19

is the intranasal vaccine recomended?

Answer 19

NO

Question 20

virus associated with Reyes syndrome and Guillan Barre?

Answer 20

Type B H flu

Question 21

wt protein in H flu lowers mucus viscosity?

Answer 21

neuroamidase

Question 22

major cause of the common cold? hw many immunotypes?

Answer 22

Rhinovirus

100

Question 23

wt protein could be targeted for a universal vaccine?

Answer 23

nucleocapsid protein

Question 24

structure of picornavirus?

Answer 24

+ ss RNA non segmented icosahedral

Question 25

which echovirus can cause respiratory illness?

pts it is severe?

Answer 25

D68

kids w asthma

Question 26

conditions caused by type 1 parainfluenza?

Answer 26

Croup, ARD, colds, pharyngitis, coryza, pharyngitis

Question 27

conditions caused by typee 2 parainfluenza?

Answer 27

croup

Question 28

3 conditions caused by type 3 and 4 parainfluenza virus?

Answer 28

ARD, bronchitis, pneumonia

Question 29

4 reasons vaccine is impractical for rhinovirus?

Answer 29

cant grow in culture
short immunity, IgA
many serotypes
in individual geographic location

Question 30

wt is unique about coronaviridae?

Answer 30

peplomers due to two glycoproteins in envelope

Question 31

virus causing SARS? why?

other thing it causes?

Answer 31

Coronavirus
binds angiotensin-converting enzyme 2 on epithelial cells (ACE2)

bronchitis in adults

Question 32

wt prevented spread of SARS-CoV?

Answer 32

quarantine

Question 33

wc virus can induce latent respiratory infections?

Answer 33

adenovirus

Question 34

where does adenovirus replicate?

Answer 34

nucleus

Question 35

wt is adenovirus capsid composed of?

Answer 35

252 hexons

12 pentons

Question 36

2 adenovirus types that cause acute respiratory disease in children and military recruits?

Answer 36

type 4 and 7

Question 37

receptor and co receptor for coronavirus?

Answer 37

metalloprotease

N-acetyl neuramic acid