Botox info

Question 1

What receptor does botox work on?

Answer 1

Muscarinic Acetylcholine receptors

Question 2

How does botox work?

Answer 2

Works on cholinergic receptors inhibiting the release of acetylcholine and causing muscle paralysis.

Question 3

Is botox reversible?

Answer 3

No

Question 4

How is botox metabolised?

Answer 4

By the liver

Question 5

How is botox excreted?

Answer 5

Via the kidneys.

Question 6

How are unused botox molecules used ?

Answer 6

Any botox molecules which remain free and do not bind are pinocytosed.

Question 7

What happens to the muscles when botox wears off?

Answer 7

Recovery of function is a gradual process over 3-6 months as nerve terminals sprout and reconnect the motor endplate.

Question 8

Name the 4 main injection sites for botox.

Answer 8

Frontalis
corrugator
Glabella
peri-orbital

Question 9

What are the main drugs to avoid with botox?

Answer 9

Aminoglycoside antibiotics - can increase therapeutic effect.
Aspirin and warfarin - can increase risk of bleeding.

Question 10

What illness can you not have botox with?

Answer 10

Myasthenias gravis - neuromuscular condition that causes muscle weakness.