Psychiatry Flashcards

1
Q

What is the most likely diagnosis?

A

Attention deficit/hyperactivity disorder (ADHD). ADHD is estimated to affect up to 8% of U.S. school-age children. Males are more affected than females, and children in North America are diagnosed with ADHD more often than children in other countries.

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2
Q

What are the typical manifestations of ADHD?

A

ADHD is characterized by hyperactivity, impulsivity, and inattention that lead to significant impairment. Hyperactivity manifests as fidgetiness and an inability to remain seated or play quietly. Impulsivity is displayed as the inability to wait for one’s turn, talking when inappropriate, and constantly interrupting. Inattention is characterized by forgetfulness, poor concentration, an inability to finish tasks, and a lack of attention to detail. To meet the Diagnostic and Statistical Manual of Mental Disorders diagnostic criteria for ADHD, symptoms must be present before the age of 7 years, persist for at least 6 months, and be present in more than one setting (eg, at home and at school).

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3
Q

What are the known risk factors for ADHD?

A

Pregnant women who smoke or use drugs are at increased risk for having children with ADHD. Genetics also plays an important role, as one in four children with ADHD has at least one relative with the condition.

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4
Q

What is the appropriate treatment for ADHD?

A

Treatment includes behavioral interventions, pharmacological therapy, or both. Although it may seem counterintuitive, stimulants have shown great effect in treating patients with ADHD. Stimulants such as methylphenidate and dextroamphetamine act by increasing catecholamine release.

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5
Q

What is the natural course of ADHD?

A

Many patients with ADHD find that they “outgrow” it during adolescence. For a subset of patients, however, the disorder continues into adulthood; these patients benefit from pharmacotherapy.

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6
Q

What is the most likely diagnosis?

A

Autism

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7
Q

What is the classic triad of findings in Autism?

A
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8
Q

What is the epidemiology of Autism?

A

Autism is relatively rare, with a prevalence of approximately 2 per 1000 children. More common in boys (male-to-female ratio is approximately 4:1), autism presents in early childhood but is a lifelong condition. In addition, up to 70% of autistic children also meet the diagnostic criteria for mental retardation.

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9
Q

What is the etiology of Autism?

A

Autism is a heterogeneous disorder with a significant, although as yet uncharacterized, genetic component. There is no scientific evidence that vaccination causes autism.

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10
Q

What 3 other conditions should be considered in the differential diagnosis to Autism?

A
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11
Q

What is the appropriate treatment for Autism?

A

Behavior therapy and educational interventions can help many autistic individuals reduce maladaptive behaviors and gain greater functional independence.

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12
Q

This patient displays symptoms of what category of psychiatric disorders?

A

This patient’s symptoms are within the spectrum of mood disorders; specifically, she manifests symptoms of a manic episode of bipolar disorder. Other disorders in this class include major depressive disorder, dysthymic disorder, and bereavement.

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13
Q

What signs and symptoms are commonly associated with Bipolar Disorder?

A
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14
Q

How is Bipolar Disorder classified?

A
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15
Q

What are the appropriate treatments for Bipolar Disorder?

A

First-line drugs include mood stabilizers (lithium, valproate, or carbamazepine) and antipsychotic agents (olanzapine, haloperidol, or risperidone). Hospitalization may be necessary to ensure patient safety.

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16
Q

What is the most likely diagnosis?

A

Major depressive disorder.

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17
Q

What symptoms are commonly associated with Major depressive disorder?

A

The diagnosis of major depressive disorder requires two or more episodes of five of the following symptoms, present for at least 2 weeks: Sleep disturbances, decreased Interest, Guilt, decreased Energy, decreased Concentration, change in Appetite (usually decreased), Psychomotor retardation, and Suicidal ideations (mnemonic: SIG E CAPS) in addition to depressed mood. This patient cannot be diagnosed until additional symptoms are determined.

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18
Q

What other conditions can present with similar symptoms to Major depressive disorder?

A

Bereavement can present with depressive symptoms within 1 year of the loss of a loved one, but symptoms are related to that loss. Grief is characterized by shock, denial, guilt, and somatic symptoms. Depressive symptoms can also suggest dysthymia, a milder form of depression with less intense symptoms that lasts at least 2 years. **Adjustment disorder with depressed mood **also presents as a milder form of depression, but symptoms are usually in response to a significant psychological stressor (eg, marital or financial problems) and usually last less than 6 months.

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19
Q

What is the epidemiology of major depressive disorder?

A

Women are diagnosed with major depression at approximately twice the rate of men. Studies show that living in urban areas, being of lower socioeconomic status, and being married (for women only) are independent risk factors for major depression.

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20
Q

What neurotransmitter disturbances are common in ajor depressive disorder?

A

Patients with major depressive disorder commonly have decreased levels of serotonin and norepinephrine. Dopamine may also be decreased in major depression.

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21
Q

What are the appropriate treatments for major depressive disorder?

A

Psychotherapy, antidepressants (including selective serotonin reuptake inhibitors, monoamine oxidase inhibitors, and tricyclic antidepressants), or both may be appropriate. Electroconvulsive therapy can be used for major depressive disorder that is refractory to other treatments.

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22
Q

What is the most likely diagnosis?

A

Generalized anxiety disorder (GAD).

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23
Q

What signs and symptoms are commonly associated with Generalized anxiety disorder (GAD)?

A
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24
Q

What other conditions should be considered in the differential diagnosis to Generalized anxiety disorder (GAD)?

A

“Normal” worry and adjustment disorder should also be considered. Unlike individuals with normal anxiety, patients with GAD have evidence of social dysfunction secondary to the disorder. Adjustment disorder is characterized by emotional symptoms following an identifiable stressor (eg, divorce or loss of a job) and lasts < 6 months. By contrast, symptoms in GAD persist for > 6 months.

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25
Q

What are the appropriate treatments for Generalized anxiety disorder (GAD)?

A
  1. Antidepressants (selective serotonin reuptake inhibitors).
  2. Buspirone (a serotonin receptor partial agonist).
  3. Benzodiazepines (fast-acting sedatives).
  4. Cognitive-behavioral therapy.
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26
Q

What is the danger of using benzodiazepines to treat Generalised Anxiety Disorder (GAD)?

A

While benzodiazepines show beneficial effects in the short term, they are not recommended for long-term use, as they are associated with the development of tolerance, physical dependence, withdrawal, and addiction.

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27
Q

What is the most likely diagnosis?

A
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28
Q

What is the epidemiology of OCD?

A

OCD occurs in approximately 3% of the general population. Males are much more frequently affected than females. The disorder often runs in families and may be associated with tic disorders (eg, Tourette syndrome).

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29
Q

What are the appropriate treatments for OCD?

A

Selective serotonin reuptake inhibitors and clomipramine are common pharmacologic treatments. Cognitive-behavioral therapy is also used with and without pharmacologic therapy.

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30
Q

What is cognitive-behavioral therapy?

A

Cognitive-behavioral therapy is a manualized, time-limited type of psychotherapy that seeks to modify a patient’s emotions by identifying and adjusting maladaptive thought patterns and beliefs. In this patient, for example, turning 30 may represent the beginning of adulthood and the end to the impulsiveness of youth. The maladaptive thought may be, “If I count to 30, I am in control and an adult.” The cognitive component of therapy will challenge this irrational thought. The behavioral component will allow him to combat the need to count or check.

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31
Q

What comorbidities are associated with OCD?

A

The prevalence of major depressive disorder among individuals with OCD is as high as 30%. Panic disorders and social phobia also commonly coexist with OCD.

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32
Q

What is the most likely diagnosis?

A

This patient exhibits traits consistent with obsessive-compulsive personality disorder (OCPD). Personality traits are patterns of relating to or thinking about the world that are exhibited in various social and personal contexts. A personality trait becomes a personality disorder when the traits are extreme and/or exclude other traits, causing personal distress, problems functioning, and an adverse impact on the social environment. A person is often not aware of maladaptive personality traits.

33
Q

How are personality disorders classified?

A
34
Q

How is Obsessive-compulsive personality disorder (OCPD) differentiated from obsessive-compulsive disorder (OCD)?

A

Obsessive-compulsive disorder (OCD) is a disorder involving obsessions and compulsions, both of which are irresistible and unpleasant to the patient (egodystonic). In OCPD, patients have a rigid preoccupation with order and control. However, they view their beliefs and behaviors simply as part of who they are (egosyntonic).

35
Q

What is the first-line treatment for obsessive-compulsive personality disorder (OCPD)?

A

Both cognitive behavioral therapy and psychodynamic psychotherapy can be useful in patients with OCPD. Medications can be used to treat comorbid conditions like anxiety and depression.

36
Q

What is the most likely diagnosis?

A

Panic disorder.

37
Q

How are panic attacks related to panic disorder?

A
38
Q

What other conditions must be ruled out before a diagnosis of panic disorder can be made?

A

Organic causes of symptoms (including tachycardia, hyperthyroidism, hyperparathyroidism, pheochromocytoma, hypoglycemia, seizure, and drug use) must be ruled out before panic disorder can be diagnosed.

39
Q

What are the appropriate treatments for panic disorder?

A

Panic disorder is often treated with selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and monoamine oxidase (MAO) inhibitors. These drugs influence levels of norepinephrine, serotonin, and γ-aminobutyric acid in the central nervous system. Benzodiazepines are also useful in the short term.

40
Q

What are the appropriate treatments for panic disorder?

A

Panic disorder is often treated with selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and monoamine oxidase (MAO) inhibitors. These drugs influence levels of norepinephrine, serotonin, and γ-aminobutyric acid in the central nervous system. Benzodiazepines are also useful in the short term.

41
Q

What syndrome can develop when SSRIs are used with MAO inhibitors?

A
42
Q

What is the most likely diagnosis?

A

Posttraumatic stress disorder (PTSD). PTSD is a complex and heterogeneous disorder characterized by reliving an extremely traumatic event with symptoms of increased arousal and avoidance. The disturbance must last more than 1 month and cause significant social and occupational distress.

43
Q

What causes PTSD?

A

PTSD is caused by any event that exposes an individual to real or threatened death or injury. The individual’s response to the event must involve intense fear and horror. Examples include military combat, sexual or physical assault, accidents, and natural disasters.

44
Q

How do patients with PTSD relive the traumatic event?

A

Recurring distressing dreams or intrusive thoughts of the event are common. Patients may also describe flashbacks in which they feel as if the event is recurring. Flashbacks are often triggered by stimuli that are common to the traumatic event such as sights, smells, or sounds.

45
Q

In what ways do patients cope with PTSD?

A

PTSD patients often avoid thoughts, feelings, stimuli, and conversations that are associated with the trauma. Because of this, it is often difficult for patients to talk about their experience. They also display a restricted range of affect, often described as “numbness” or “detachment.”

46
Q

What symptoms may be present in PTSD?

A

PTSD is characterized by hyperarousal that may manifest as insomnia, bouts of rage, hypervigilance, being easily startled, or having poor concentration.

47
Q

What treatment options are available for PTSD?

A

Selective serotonin reuptake inhibitors are usually the first line of treatment for PTSD. Tricyclic antidepressants and monoamine oxidase inhibitors can be used to decrease symptoms of hyperarousal. Effective psychotherapy includes cognitive behavior therapy, exposure therapy, and anxiety management.

48
Q

What is the most likely diagnosis?

A

Rett disorder is a neurodevelopmental disorder characterized by initial normal development during the first 6–18 months of life followed by a loss of speech and loss of purposeful hand movements.

49
Q

What are the genetics of Rett disorder?

A

Rett disorder is an X-linked disorder affecting only females. Affected males die in utero. The disorder is caused by mutations in the MECP2 gene, which encodes for a methyl-binding protein. This protein is most abundant in the brain and is thought to act as a gene suppressor during development.

50
Q

What is the progression of Rett disorder over time? (4 stages)

A
51
Q

What is the treatment and prognosis for patients with Rett disorder?

A

Treatment for Rett disorder is aimed at alleviating symptoms with careful management of nutrition, pharmacotherapy for seizures, speech therapy for language dysfunction, and physical therapy for motor dysfunction. Patients can generally live for decades with successful management of symptoms.

52
Q

What is the most likely diagnosis?

A

The constellation of symptoms suggests schizophreniform disorder, which is the presence of psychotic symptoms for > 2 weeks but < 6 months. This contrasts a diagnosis of schizophrenia, which requires the presence of symptoms for at least 6 months. The majority of patients with schizophreniform disorder ultimately develop schizophrenia.

53
Q

What symptoms are associated with schizophreniform disorder?

A

Patients with psychosis can present with positive and negative symptoms. Positive symptoms include formal thought disorder (disorganized speech and loosening of associations), delusions (often persecutory in nature), hallucinations (most commonly hearing voices), and ideas of reference (beliefs or perceptions that irrelevant, unrelated, or innocuous things are referring to a person directly or have a special significance for that person). Negative symptoms include flat affect, social withdrawal, and avolition (inability to initiate and maintain goal-directed activities).

54
Q

What other conditions should be considered in the differential diagnosis to schizophreniform disorder?

A
  1. Brief psychotic disorder: The symptom criteria are the same as for schizophrenia, but the duration of symptoms is < 1 month. Prognosis is generally good.
  2. Schizoaffective disorder: The symptom criteria are the same as for schizophrenia, but the patient must also have at least one concurrent major mood episode (ie, major depressive disorder or mania).
55
Q

What are the appropriate pharmacologic treatments for schizophreniform disorder?

A

** Typical antipsychotics **(such as thioridazine, haloperidol, fluphenazine, and chlorpromazine) block dopamine-2 receptors. This class of drugs carries a higher rate of extrapyramidal side effects, including muscle rigidity, body posturing, akathisia (feeling of restlessness), and Parkinson-like tremors.

56
Q

What is the most likely diagnosis?

A

Somatization disorder.

57
Q

What are common symptoms of Somatization disorder?

A

To meet diagnostic criteria, patients must present with somatic complaints in at least four sites: two gastrointestinal, one neurologic, and one sexual.

58
Q

How are other conditions in the category of Somatization disorders differentiated?

A
59
Q

What other conditions must be distinguished from Somatization disorder?

A
60
Q

What is the most likely diagnosis?

A

Steroid-induced mania.

61
Q

What drugs are most commonly associated with these symptoms of drug-induced mania?

A

Drug-induced mania can be secondary to ingestion of cocaine or amphetamines. Corticosteroids are a common iatrogenic cause of mood symptoms.

62
Q

What 5 signs and symptoms are commonly associated with drug-induced mania?

A
  1. Dilated pupils.
  2. ECG arrhythmia or ischemia.
  3. Hypertension.
  4. Mood elevation, general activation.
  5. Tachycardia.
63
Q

What laboratory tests are useful in confirming the diagnosis of drug-induced mania?

A

Urine or serum toxicology screening can identify specific drugs the patient may have ingested. Medications should be reviewed for possible iatrogenic cause.

64
Q

What are the appropriate treatments for steroid-induced mania?

A

Steroids are appropriate but the dose should be reduced as much as clinically possible. If agitation or psychotic symptoms are present, haloperidol is useful, sometimes with lorazepam. Calcium channel blockers can be used for acute autonomic symptoms.

65
Q

These symptoms could also be seen in which other psychiatric disorders?

A

These symptoms could also be evidence of delirium or a manic phase of bipolar disorder.

66
Q

What is the most likely diagnosis?

A

Tardive dyskinesia. Extrapyramidal symptoms, such as stereotypic oral, buccal, or lingual movements and choreiform or athetoid movements, can occur after several months or years of therapy with antipsychotic agents. These symptoms are often irreversible.

67
Q

What is the pathophysiology of Tardive dyskinesia?

A

Although the exact mechanism is poorly understood, it is hypothesized that dopamine-2 receptor supersensitivity after long-term use of antidopaminergic drugs is the cause.

68
Q

What 4 risk factors are associated with Tardive dyskinesia?

A
  1. Diabetes mellitus.
  2. History of movement disorders.
  3. Tobacco use.
  4. Typical antipsychotic agents (strong risk factor, especially at higher doses for longer periods).
69
Q

What other movement abnormalities, aside from tardive dyskinesia, are associated with the use of antipsychotic agents?

A
  • Acute dystonia is the earliest symptom to present (within hours) and is characterized by sustained muscle spasms of the face, neck (spasmodic torticollis), and eye (oculogyric crisis).
  • Akathisia, characterized by extreme restlessness and an inability to sit still, is the most common extrapyramidal disorder.
70
Q

What can be done to minimize the risk of these symptoms of tardive dyskinesia continuing?

A

Lowering the dose of typical antipsychotic agents can help resolve symptoms. However, this may produce a transient worsening of dyskinesia as receptors become desensitized. Switching patients to atypical antipsychotic agents is advised, as they are associated with fewer extrapyramidal symptoms. Clozapine is the least likely of all antipsychotic drugs to cause tardive dyskinesia and is also the only medication to treat it. However, its use is limited by the need for routine blood monitoring, a high degree of both benign and serious side effects, and its availability only as an oral preparation.

71
Q

What is the most likely diagnosis?

A

This patient displays criteria for Tourette disorder, which is characterized by multiple motor and vocal tics present since childhood. A tic is a sudden, stereotypical, repetitive movement or vocalization. The tics in Tourette disorder occur many times a day for at least 1 year.

72
Q

What is the epidemiology of Tourette disorder?

A
73
Q

What motor abnormalities are seen in Tourette disorder?

A

Motor tics can be simple or complex and can affect any part of the body. Often, patients will initially have simple tics such as blinking, shoulder shrugging, head jerking, or grimacing. Complex tics may involve jumping, squatting, turning, or obscene gestures (copropraxia).

74
Q

What vocal abnormalities are seen in Tourette disorder?

A

The classic vocal tic is coprolalia, or involuntary vocalization of obscene words. Other vocal tics include echolalia (repetition of others), and sounds such as barking, coughing, sniffing, grunting, or snorting.

75
Q

What vocal abnormalities are seen in Tourette disorder?

A

The classic vocal tic is coprolalia, or involuntary vocalization of obscene words. Other vocal tics include echolalia (repetition of others), and sounds such as barking, coughing, sniffing, grunting, or snorting.

76
Q

Are the tics of Tourette disorder involuntary?

A

Yes, the tics are involuntary, but for brief periods patients may be able to consciously suppress them. Patients often describe a sense of relief once the tic is performed.

77
Q

What is the natural history of Tourette disorder?

A

Onset is usually during childhood and must occur before 18 years of age. The disorder may be lifelong, but many patients find that the severity of the tics decreases with age.

78
Q

What is the appropriate treatment for Tourette disorder?

A

In many cases, education and reassurance may be sufficient. If the tics significantly interfere with the patient’s social interactions, a dopamine antagonist (such as haloperidol) can be effective.