lecture 10 ( Intracellular Compartments and Protein Transport) Flashcards
What is the function of glycosylation?
It provides stability to proteins to function properly and aid in the folding.
Why is modification important to proteins?
because the function of the protien depends on the modifications that occur in the ER and Golgi apparatus
True or False: the protein can enter golgi even if it was’nt folded properly
FALSE
How do protein move to the lysosome?
ER –> Golgi –> through vesicles it travels to the lysosomes
What is glycosylation?
the process of producing glycoprotein from the addtion of glucose to a protein before folding
Affects of glycosylation:
- allows the cell to produce large amounts of different proteins from single gene
In glycosylation modification ————- is attached to protein
oligosccharides
What is the 2 types of attchement formed when oligosaccharide attches to protein?
1) N-linkage the nitrogen atom on the side of asparagine (amino acid) attaches to protein.
2) O-linkage the oxygen atom on the side of threonine and serine (amino acid) attaches to protein.
What are the three different amino acid that can be glycosylated?
1) Asparagine
2) serine
3) threonine
Origin and destination of clathrin coated +adaptin 1:
O: Golgi
D: lysosome via endosome
What is the original and destination of clathrin +adaptin 2?
O: plasma membrane
D: endosome
What are the three sensors for misfolded proteins in the ER?
IRE1
ATF6
PERK (Inhabits protein synthesis)
What triggers an unfolded protein response UPR in the ER lumen?
Accumulation of Misfolded proteins
What is the function of Chaparron’s?
It helps misfolded proteins to fold properly
