Infectious Disease Pt 1 Flashcards

1
Q

An 18 month old baby has had a hoarse, barking cough, rhinorrhoea, and low grade fever; he develops stridor when agitated. Findings include: rectal temperature of 101F, RR of 28 and mild stridor on agitation.
What is the Dx and Rx?

A

croup

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2
Q

In patients with croup, you can expect to hear stridor on inspiration or expiration?

A

Inspiration

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3
Q

What is the hallmark of croup in infants and young children? What about older children and adults?

A

barking cough in infants/young kids and horseness in older kids/adults

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4
Q

Croup, by definition, is inflammation of what?

A

larynx and trachea

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5
Q

What if you notice your patient has inflammation of the larynx, trachea, and bronchi? What is your diagnosis?

A

LTB–laryngotrachobronchitis

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6
Q

What typically causes croup?

A

viral infection

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7
Q

Your patient is very horse but does not have a cough, and lung sounds are normal. What is your likely diagnosis (assuming not cancer)

A

Laryngitis

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8
Q

LTBP (laryngotracheobronchopneumonitis) is a more serious “croup-like” infection. Aside from more extensive inflammation of the airways, what makes it more serious?

A

Often complicated by bacterial superinfection

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9
Q

If viral infections commonly cause croup, which ones are predominately to blame?

A

Most common is PARAINFLUENZA VIRUS TYPE 1. Also caused by RSV and adenoviruses. And measles in certain populations
(Rarely caused by the flu)

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10
Q

You suspect your patient has croup, but it does not appear to be a viral infection, what pathogens are in your differential?

A

Staph, strep, and s. pneumonia

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11
Q

What age group is most susceptible to croup? And WHEN does it usually occur?

A

kids 6-36 months, occurs late fall/early winter along with the parainfluenza type 1 virus

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12
Q

You have 2 kids that are 24 months old, it is November and they both had a recent fever, and runny nose. One of the kids has a history of bacterial pneumonia, the other has a history of seasonal allergies. Which one are you more worried about? Why?

A

Seasonal allergies. Because kids with hypersensitivities (like allergies or asthma) are more predisposed to clinically significant narrowing of the upper airway during a croup infection.

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13
Q

You suspect a young child has croup. When do you decide to order a CXR? What are you looking for to confirm your diagnosis?

A

CXR typically not warranted, only if child has significant obstruction or is at risk for rapid progression of airway obstruction. You will be looking for the steeple sign

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14
Q

You have a strong suspicion that your patient has croup, however you want to make sure the symptoms can’t be explained by anything else. What other things would you need to rule out?

A

1) acute epiglottitis
2) peritonsillar abscess
3) FB
4) anaphylactic rxn
5) upper airway injury

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15
Q

3 year old boy who recently emigrated from Mexico is brought to the emergency department because of sudden onset of high grade fever and respiratory distress. Findings include drooling, dysphagia, dysphonia and inspiratory stridor. He is sitting, leaning forward with neck hyperextended.
What is the Dx and Rx?

A

acute epiglottitis

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16
Q

What pathogen is typically responsible for epiglottitis?

A

could be bacterial, viral, or fungal. Most common in children is Hib (haemophilus influenza b). No telling with the adults

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17
Q

What are the classic signs of epiglottitis?

A

respiratory distress, anxiety, tripoding/sniff position, drooling, dysphagia, fever, sore throat, hot potato voice

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18
Q

If you notice a child with classic symptoms of epiglottitis who appears to be in distress, what should you do?

a) examination with tongue blade to confirm
b) if O2sat is stable, give them inhaled steroids
c) if O2sat is stable, oral steroids and abx
d) send them to a place where airway can be secured prior to evaluating any further
e) get Xray to check for thumbprint sign first and then treat accordingly

A

D! Epiglottitis poses a serious risk to airway and any irritation to airway or delay in securing airway could be life threatening

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19
Q

After airway is secure, what is the treatment for epiglottitis for a child 6 years?

A

6, check level of obstruction. >50% get intubated and <50% should be observed in ICU. Both groups get cephalosporins (ceftriaxone) AND anti staph med like vancomycin.

***Fun Fact: All children under 6 require intubation

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20
Q

A 4 month old previously healthy infant presents in January with a 2 day history of coughing and breathing difficulty and a 1 day history of refusing to take oral fluids. He has no history of choking. Physical examination reveals a pale infant who has dry mucous membranes, retractions, RR of 50 and breath sounds decreased bilaterally with diffuse expiratory wheezing.
What is the Dx?

A

bronchiolitis

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21
Q

How do you tell the difference between bronchiolitis and asthma, since they both are characterized by wheezing and airway obstruction?

A

They may overlap, but bronchiolitis is due to a primary infection important to take good history

22
Q

What is the most common cause of bronchiolitis?

A

RSV is most common. (also rhinovirus and many more…but all viral)

23
Q

What is the pathogenesis of bronchiolitis?

A

Viruses attack epithelial cells lining respiratory mucosa which causes inflammation

24
Q

What is a virus that causes respiratory tract infections? It is a major cause of lower respiratory tract infections and hospital visits during infancy and childhood. This virus often has the same symptoms as a cold, but puts young patients at increased risk for respiratory complications.

A

Respiratory Syncytial Virus (RSV)

25
Q

What are risk factors for developing severe RSV?

A

premature babies, low birth wt, <12 weeks old, people with underlying chronic pulmonary dz, congenital heart defects, immunocompromised patients, exposure to smoke, native americans, daycare

26
Q

Your patient is tachypnic, having retractions, and you hear rales and expiratory wheezing on exam. You also notice hyperexpansion of the chest. What the heck is going on? How will you treat it?

A

bronchiolitis. Treatment is supportive. Hydration, O2 if needed. Steroids use is controversial and most opt against

27
Q

Can adults get bronchiolitis?

A

Yes, not as commonly. Only difference b/t bronchiolitis and bronchitis (no body got time) is the involvement of the bronchioles

28
Q

When adults do get bronchiolitis, what pathogen is the cause?

A

TRICKSTER. Cause is not always infectious. Can be inhalation injury, drug induced, connective tissue disorder, etc. The point is….bronchiolitis in adults is very diverse

29
Q

So your adult patient is having a dry cough, dyspnea, fatigue, and malaise for 2 months. At first you thought it was bronchiolitis, but they just aren’t getting better despite 2 courses of antibiotics. You decide to order a CXR and see bilateral patchy infiltrates. Also you get a PFT (I really wanted to say PFT test) that is showing a restrictive defect. What the heck is going on? How will you treat it?

A

COP–cryptogenic organizing PNA (which is apparently the same thing as BOOP?) You’re gonna go ahead and give steroids for up to 3 months and then slowly titrate off over 6 months

30
Q

So you’ve got a productive cough that’s been going on for two weeks now. Your throat is sore, you have a stuffy nose and a headache. You haven’t noticed a fever, but you haven’t had any energy. Seriously, there is not any time for this inconvenience in your schedule. What do you have? What is your treatment?

A

BRONCHITIS. Go get a cold pop. (reassurance and symptomatic treatment only, abx are not supported)

31
Q

When do you classify bronchitis as “chronic”

A

If you have 2 episodes that last >3 months in a 2 year period

32
Q

What is the most common cause of bronchitis?

A

Viruses! which is why a cold pop works just as well as an antibiotic

33
Q

If you’ve been diagnosed with bronchitis and you develop a fever, should you be worried? What should you do?

A

Call your doctor, fevers with these symptoms should raise a red flag for PNA

34
Q

Your patient has a cough. It could be anything. What is your DDx? Meaning, what causes cough?

A

bronchitis, pna, PND, GERD, asthma, ACEI’s

35
Q

Ok, so there are actually a couple reasons you’d want to give abx for bronchitis. What are the exceptions?

A

If it’s caused by pertussis!! Immunosuppression, your patient is elderly (>65) AND have recently been in the hospital, have DM, CHF, or are using glucocorticoids. Or if they are >80. Use judgement in giving abx to patients with heart/lung/renal/liver dz
PERTUSSIS! I starred that one, its the only time in healthy people.

36
Q

Which of the following is true about Pertussis:
A) The organism causing pertussis is a gram-negative bacteria
B) Predominantly characterized by cough with high fevers for weeks
C) Diagnosis is by blood cultures
D) Treatment is usually with Penicillins
E) Treatment for households is not recommended

A

it is gram negative

37
Q

Pertussis is known for uncontrollable, violent coughing which often makes it hard to breathe. After fits of many coughs, someone with pertussis often needs to take deep breathes which result in a “whooping” sound. What pathogen causes pertussis?

A

The bordetella pertussis bacterium

38
Q

How contagious is bordetella pertussis?

A

highly

39
Q

what does paroxysmal mean?

A

sudden

40
Q

At your peds rotation, the doctor tells you the next patient has pertussis. What symptoms will you expect?

A

paroxysmal cough, inspiratory “whooping” sound, post-tussive emesis.

41
Q

The parent of a child diagnosed with pertussis tells you their kid had a mild cough for 3 weeks, coryza (cold-like symptoms), but no fever before developing the more severe coughing and post-tussive emesis. Is this an atypical presentation? What would you tell the parents, since they are so worried you don’t know what you are talking about? What can they expect over the next couple week?

A

Tell them that is a very classic presentation of pertussis. The mild symptoms are actually called the “prodromal state”. Right now, the patient is in the “paroxysmal phase” and having the worst of his symptoms. You can reassure the parent by telling them to expect a milder chronic cough for several more weeks, this is the “convalescent stage”

42
Q

What would you prescribe, if anything, for a patient with pertussis?

A

Macrolides (azithromycin)

43
Q

Do you make a pertussis diagnosis clinically? Or do you have to run tests?

A

Typically a diagnosis made clinically, but can confirm with a nasopharyngeal culture. Will also see elevated leukocytes and lymphocytes on CBC

44
Q

What if pertussis goes untreated? What is the most serious complication?

A

bronchopneumonia

45
Q

You woke up with headache, fever, chills, muscle aches, sore throat, malaise, and a cough. This is lame. What do you think is going on?

A

the flu

46
Q

You are healthy, and you know the flu is a virus, and you would not be stupid enough to ask the doctor for an antibiotic UNLESS….?

A

you started to get better and then you got worse again. This is a red flag that a bacterial infection has developed on top of the flu.

47
Q

What is the most common complication of the flu? Who are the culprits?

A

pneumonia, could be viral pna or caused by STAPH, strep pneumonia, Hflu

48
Q

As a provider, how will you diagnose the flu?

A

Clinical (H&P). Can also use NP swab, but be aware swabs are very specific and therefore non-sensitive, meaning there will be false negatives

49
Q

How do you treat patients with an uncomplicated flu?

A

symptomatically. Avoid ASA in pts <18 (increased likelihood of Rye syndrome)

50
Q

Your patient is high risk and has the flu (old or young or immunocompromised, etc). How will you treat them?

A

Oseltamivir ASAP + symptom relief. Monitor for development of pna

51
Q

who should be getting a flu shot?

A

everybody > 6 months