Non-Malignant Morphology

Question 1

Dhole Body

Answer 1

Blueish inclusion
Remanants of RER
Seen with inflammations, GCSF
Not in all neutrophils

Question 2

May Hegglin Anomoly

Answer 2

Dhole bodies in all neutrophils
Macrothrombocytopenia
MYH9
Epstein syndrome, Fechtner syndrome

Question 3

Chediak Higashi

Answer 3

AR disorder of lysosymal biogenesis CHS/LYST gene
large azurophilic granules in neutrophils and lymphocytes +MPO
Immunodef and oculocutaneous albinism, accelerated HLH

Question 4

Pelger Huet Anomoly

Answer 4

bilobed nucleus of neutrophils in heterozygous mutations of laminin B
Homozygotes have unilobed nucelus
Still functional, all neutrophils will have if genetic, if stress will just be some

Question 5

Alder-Reilly anomoly

Answer 5

prominent azurophilic granulation of all leukocytes due to lysosomal buildup of mucopolysaccharide (nml RBCs and plts)

Question 6

Bordatella Pertusis

Answer 6

Lymphocytes with clefted nucelus

Question 7

Lysosomal storage disorder

Answer 7

vacuolated lymphocytes
mucopolysaccharidosis, galactosialidosis, mucolipidosis, GM1 gangliosidosis

Question 8

Beta Thalassemia

Answer 8

Basophilic stippling evenly distributed

Question 9

Sideroblastic anemia

Answer 9

basophilic stippling more clumped and papenheimer bodies
ringed sideroblasts = iron granules surrounding nucleus
x-linked sideroblastic anemia from ALAS2

Question 10

G6PD

Answer 10

heinz bodies (precipitated oxidized hemoglobin), blister cells

Question 11

Stomatocytosis

Answer 11

mutation of RHAG gene overhydrated cells, increased osmotic fragility, low MCHC

Question 12

Howell Jolly Bodies

Answer 12

Nuclear remnants
Splenectomy
severe hemolytic anemia
megaloblastic anemia
CDA
premature infants

Question 13

Basophilic stippling

Answer 13

aggregated ribosomes
lead poisoning
thalassemia
Pyrimidine 5’nucleotidase deficiency
hemoglobinopathy
MDS
CDA

Question 14

Pappenheimer bodies

Answer 14

lysosymes containing iron complexes
irregular clusters
Asplenia
iron overload
thalassemia
hemolytic anemia
CDA
sideroblastic anemia
hemoglobinopathies

Question 15

Heinz bodies

Answer 15

denatured hemoglobin
G6PD
oxidative drug
homozygous hemoglobinopathies

Question 16

Hemoglobin H

Answer 16

Alpha thalassemia
precipitates of beta globin

Question 17

CDAN

Answer 17

RBC precursers abnormal
CDAN1 - binucleated with nuclear bridging
CDAN2 - all binucleated, positive HAM test
CDAN3 - multinucleated

Question 18

Megaloblastic anemia

Answer 18

Motheaten (reticulated) erythroid precursors, giant bands, nuclear cytoplasmic dysynchrony
DHFR deficiency (folate transporter)
Hereditary orotic aciduria

Question 19

Gaucher

Answer 19

large macrophages with wrinkled tissue paper (lysosymes stuffed with glycosphingolipids)

Question 20

Niemann-Pick

Answer 20

Sphingomyelinase deficiency (SMPD1 gene)
large macrophages with foamy lysosymes

Question 21

Microthrombocytopenia

Answer 21

WAS, x-linked thrombocytopenia
MPV<7

Question 22

Macrothrombocytopenia

Answer 22

MPV > 11
MYH9
Bernard Soilier
DiGeorge
Paris Trousseau
Grey Platelet Syndrome
Sitosterolemia