Excretory System Flashcards

1
Q

The glomerulus exits the Bowman’s capsule via which vessel?

A

Efferent arteriole

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2
Q

Characteristics of marine fish:

A

Saltwater fish
Hypoosmotic to their environment- less salty than the surrounding saltwater
Constantly loosing water to their environment
Constantly drink water
Rarely urinate
Urine is very concentrated to minimize water loss from extraction
Secrete accumulated salts through their gills

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3
Q

Characteristics of freshwater fish:

A

Hyperosmotic compared to their environment
More salty than the surrounding freshwater
Constantly absorbing too much water (gain water from the environment)
Rarely drink water
Constantly urinate
Very dilute urine
Absorb salts through their gills

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4
Q

What are the functions (5) of the kidneys?

A

1) Regulate blood pressure
2) Maintenance of blood pH
3) Stimulate the production of RBCs via secretion of erythropoietin
4) Regulate osmolarity
5) Filter the blood and excretion

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5
Q

Podocytes

A
  • cells of the Bowman’s capsule that wrap around the glomerulus to form fenestrations
  • filter blood by preventing large molecules (proteins, RBCs) from entering and allowing small molecules (water, solutes, sugars, vitamins, salts) to pass through
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6
Q

Reabsorption

A

Removal of water and solutes from the filtrate back into the blood vasculature

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7
Q

Where does majority of reabsorption occur? what is being reabsorbed?

A
  • In the proximal convoluted tubules
  • active reabsoption (transport) of almost all glucose, amino acids, and some NaCl
  • passive reabsorption (transport) of potassium ions and bicarbonate ions (water follows these ions out so the cortex is not salty)
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8
Q

Descending loop

A
  • High permeability to water, low permeability to salts
  • Water is reabsorbed into the blood via aquaporins
  • Filtrate becomes more concentrated (less dilute) - body’s way of reabsorbing and retaining water
  • solute concentration in the tube increases
  • water picked up by vasa recta –> medulla stays salty
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9
Q

Ascending loop

A
  • High permeability to salts, impermeable to water
  • Solutes are reabsorbed out of the filtrate and are absorbed by the vasa recta
  • Filtrate becomes less concentrated (more dilute) - body’s way of reabsorbing and retaining important salts
  • solute concentration in the tube decreases
  • makes the renal medulla salty: first passively and then actively by pumping out NaCl
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10
Q

Secretion

A

Transfer of solutions from the blood vasculature directly into the nephron tubule filtrate

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11
Q

The longer the nephron the (more/less) concentrated the urine will be. Why?

A

More, the interstitial fluid surrounding the nephron becomes more concentrated with salts which is why the longer the, the more concentrated the urine will be.

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12
Q

Where does secretion occur?

A

Proximal and distal convoluted tubules secrete products taken up from the peritubular capillaries
Proximal: urea (uric acid), creatine, drugs and other waste products are secreted via active transport
Distal: protons (H+) potassium and urea are secreted via active transport

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13
Q

Parathyroid hormone affects on calcium levels in blood:

A

Increases calcium levels in the blood by stimulating reabsorption of calcium in the tubules (as well as causing bones to release calcium)

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14
Q

Calcitonin affects on calcium levels in blood:

A

Decreases calcium levels by inhibiting reabsorption of calcium from the tubules (as well as causing bones to absorb it)

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15
Q

Antidiuretic hormone

A

(ADH or vasopressin)
Released from the posterior pituitary gland upon stimulation of the hypothalamus
Prevents diuresis, production of urine, by causing aquaporins to insert into the collecting duct of the nephron which increases water reabsorption (less water foes to urine, more water back into the body)

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16
Q

What hormone results in concentrated urine?

A

ADH (vasopressin)
If the body is dehydrated, ADH is released to absorb as much water as it can back into the body to prevent cells from dying

17
Q

Function of renin

A

An enzyme that acts on angiotensinogen to activate it to the form angiotensin I

18
Q

When is renin released?

A

When juxtaglomerular cells detect changes in blood pressure, volume (decrease) and sodium levels (decrease)
Can also be released by sympathetic nervous system activity

19
Q

What is angiotensin I converted to?

A

Angiotensin II via angiotensin converting enzyme (ACE)

20
Q

Effects of angiotensin II:

A

1) stimulates additional aldosterone release from the adrenal cortex- aldosterone levels increase
2) increases Na+ reabsorption from the proximal tubule- water will follow salt
3) it is a potent systemic vasoconstrictor- causes vessels to constrict which increases total peripheral resistance (TPR)
4) makes an individual more thirsty- they drink more water and increase their blood liquid volume (increasing TPR)

21
Q

Function of aldosterone

A
  • Increases sodium (and water follows) reabsorption in the distal convoluted tubule and collecting duct so the body can retain more ions and water, which can help maintain blood pressure
  • Increases potassium secretion in the distal tubules and collecting ducts
  • incnreases the amount of Na+/K+ antiport
  • concentration of filtrate increases as a result
22
Q

Atrial natriuretic peptide (ANP)

A

Produced by atrial cells in response to atrial dissension by increased blood volume or pressure

23
Q

What molecules filtered in the nephron are completely reabsorbed from the convoluted tubules back into the blood?

A

Glucose and amino acids are completely reabsorbed because of their importance and they must be maintained at constant levels within the blood

**the presence of glucose in urine is a sign of diabetes

24
Q

What effect does antidiuretic hormone (ADH) have on blood pressure?

A

increases blood pressure (by increasing water reabsorption in the kidneys)

25
Q

What is the effect of decreased levels of aldosterone?

A

Decrease reabsorption of sodium and water from the collecting duct (i.e there would be more water left in the filtrate)
Lowered blood pressure

26
Q

what gets secreted into the proximal convoluted tubule?

A
  • drugs, toxins, NH3
  • H+ ions are also secreted in via anti-port with Na+
27
Q

net result of the PCT is to ____ the amount of filtrate

A

reduce (but concentration stays relatively the same)

28
Q

what do PCT cells have lots of?

A

mitochondria due to all of the active reabsoption that takes place

29
Q

distal convoluted tubule

A
  • more reabsoption of glucose, ions and water so the cortex isnt salty
  • the filtrate (NaCl and bicarbonate) gets actively pulled out and reabsorbed into the body
  • K+/H+ are actively secreted into the tubule
  • some water gets passively pulled out
  • overall, filtrate concentration gets lowered
30
Q

urine is ____ to blood

A

hypertonic - contains a high urea and solute concentration