CHAPTER 13: PLATELET PRODUCTION, STRUCTURE, AND FUNCTION Flashcards

1
Q

(1) The megakaryocyte progenitor that undergoes endomitosis is:

a. MK-I
b. BFU-Meg
c. CFU-Meg
d. LD-CFU-Meg

A

d. LD-CFU-Meg

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2
Q

(2) The growth factor that is produced in the kidney and induces growth and differentiation of committed megakaryocyte progenitors is:

a. IL-3
b. IL-6
c. IL-11
d. TPO

A

d. TPO

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3
Q

(3) What platelet organelle sequesters ionic calcium and binds a series of enzymes of the eicosanoid pathway?

a. G protein
b. Dense granules
c. DTS
d. SCCS

A

c. DTS

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4
Q

(4) What platelet membrane receptor binds fibrinogen and supports platelet aggregation?

a. GP Ib/IX/V
b. GP IIb/IIIa
c. GP Ia/IIa
d. P2Y1

A

b. GP IIb/IIIa

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5
Q

(5) What platelet membrane phospholipid flips from the inner surface to the plasma surface on activation and serves as the assembly point for coagulation factors?

a. Phosphatidylethanolamine
b. Phosphatidylinositol
c. Phosphatidylcholine
d. Phosphatidylserine

A

d. Phosphatidylserine

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6
Q

(6) What is the name of the eicosanoid metabolite produced from endothelial cells that suppresses platelet activity?

a. TXA2
b. Arachidonic acid
c. Cyclooxygenase
d. Prostacyclin

A

d. Prostacyclin

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7
Q

(7) Which of the following molecules is stored in platelet dense granules?

a. Serotonin
b. Fibrinogen
c. PF4
d. Platelet-derived growth factor

A

a. Serotonin

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8
Q

(8) What plasma protein is essential to platelet adhesion?

a. VWF
b. Factor VIII
c. Fibrinogen
d. P-selectin

A

a. VWF

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9
Q

(9) Reticulated platelets can be enumerated in peripheral blood to detect:

a. Impaired production in disease states
b. Abnormal organelles associated with diseases such as leukemia
c. Increased platelet production in response to need
d. Inadequate rates of membrane cholesterol exchange with the plasma

A

c. Increased platelet production in response to need

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10
Q

(10) Platelet adhesion refers to platelets:

a. Sticking to other platelets
b. Releasing platelet granule constituents
c. Providing the surface for assembly of coagulation factors
d. Sticking to surfaces such as subendothelial collagen

A

d. Sticking to surfaces such as subendothelial collagen

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