Oral Solid Dosage Forms

Question 1

What are the Oral SDFs and non-oral SDFs

Answer 1

Oral: Tablets, capsules, oromuscular preperations
Non-oral: Suppositries, pessaries

Question 2

What is an oral SDF

Answer 2

Medicinal product delivered via the mouth in the form of a solid to be absorbed by the GI system or oral cavity - tablets capsules

Question 3

Tablets

Answer 3

-solid preperation each containing a single dose of one or more active ingridient

-obtained by compressing uniform volumes of particles or by another suitable manufacturing technique, such as extrusion, moulding, dry-freezing.

-swalloed whole, some after being chewed, some are dissolved or dispersed in water before being administred and some are retained in the mouth where the active substance is liberated.

Question 4

Capsules

Answer 4

-solid preperations with either hard or soft shells of various shapes and capasities, usulally a single dose of active substance(s).

-produced by filling the active substance into one section, then closing the capsule by slipping the other secion over it. the security of the closure may be strengthened by suitable means.

-the capsules are genereally made of gelatine and other materials, where necessary.

• contents may be solid, liquid, or paste like consistency.

-the shell is attacked by digestive fluids and contents released.

Question 5

Factors that influence the OSDF

Answer 5

Powder classification

Question 6

Powder classification

Answer 6

Size
>1000um = coarse
>100um < 1000um = intermediate
>5 um<100um = fine
<5um = ultrafine

Shape
spherical - good flow (seeds)
acicular - poor flow (twigs)

Density
more dense - heavy (golf balls)
Less dense - lighter (table tennis ball)

Question 7

Which powder flow characteristics will make particles move up

Answer 7

Large particles
non-spherical
low density

Question 8

Which powder flow characteristics will make particles move down

Answer 8

Small particles
spherical
high density

Question 9

Particle size analysis (light based methods0

Answer 9

Microscopy
-light microscopy: easy, but multiple samples need to be measured. only useful for particles visible to naked eye
SEM or TEM: ultrafine particles. useful for absorbing surface texture of particle

Laser light diffraction - size range 0.5um - 3500um

Photon correlation spectroscopy - size range 0.3nm - 10um.

Question 10

Particle size analysis (Sieving methods)

Answer 10

Sieveing
Air jet sieving
Inertial impaction