DOTD pt6

Question 1

Drug Class: Co-careldopa

Answer 1

Dopamine agonist

Question 2

Drug Class: Levetiracetan

Answer 2

Antiepileptic

Question 3

Drug Class: Lorazepam

Answer 3

Benzodiazepine
(Anxiolytic)

Question 4

Indications: Co-careldopa

Answer 4

Parkinson’s

Question 5

Indications: Levetiracetan

Answer 5

Focal seizures inc. secondary generalisation

Question 6

Indications: Lorazepam

Answer 6

Anxiety, sleep aids, alcohol withdrawal, emergency seizure control/termination in status epilepticus

Question 7

Mechanism of action: Co-careldopa

Answer 7

Supplies levodopa + is a peripheral dopa decarboxylase inhibitor

Question 8

Mechanism of action: Levetiracetan

Answer 8

Synaptic vesicle protein 2A (SV2A) inhibition

Question 9

Mechanism of action: Lorazepam

Answer 9

Increase GABA activity

Question 10

Adverse drug reactions: Co-careldopa

Answer 10

Drowsiness, hallucinations, slow loss of efficacy with time, NMS if stopped suddenly

Question 11

Adverse drug reactions: Levetiracetan

Answer 11

Anxiety, drowsiness, dizziness (same in all AEDs)

Question 12

Adverse drug reactions: Lorazepam

Answer 12

Addiction (street value), ataxia, depression, drowsiness, hypotension, muscle weakness, sleep dysfunction, respiratory depression at high doses

Question 13

Contraindications, Warnings, DDIs: Co-careldopa

Answer 13

Pyridoxine (vitamine B6) - increases peripheral breakdown of levodopa
Many antipsychotics block dopamine receptors causing parkinsonism as a SE

Question 14

Contraindications, Warnings, DDIs: Levetiracetan

Answer 14

CNS depressants

Question 15

Contraindications, Warnings, DDIs: Lorazepam

Answer 15

CNS depressants