intro lecture Flashcards
4 main functions of renal system
- BP control
- Vit D activation
- toxin removal
- RBC production
inner portion of the kidney; goal is to be hyperosmotic
meulla
collection of capillaries which leak filtrate into bowman’s space
glomerulus
primary site of reabsorption & H+ secretion
PCT
sets up concentration gradient for medulla; water passively passes from descending part
loop of henle
where ion exchange happens & where JG apparatus is
DCT
secondary urine concentration; where ADH acts
collecting duct
primary function of the JG complex
- maintain blood flow despite MAP changes
via Na sensation & BP regulation
what part of the JG apparatus senses sodium?
macula densa– sends info back to JG cells
site of synthesis, storage and release of renin
JG cells of arterioles
3 mechanisms that cause release of renin
- decreased sodium sensed by macula densa
- decreased perfusion pressure to kidneys
- sympathetic nerve activation
4 things angiotensin II does
- arteriole vasoconstriction (raise BP)
- stimulates ADH secretion (stimulate thirst and raise BP)
- enhace NaCl reabsorption in proximial tubules
- stimulates aldostrone secretion
2 things aldosterone does
- hold Na to increase BP (kick out K+)
- increase salt appetite & thirst
where do Renin inhibitors work (ends in – kiren)
stops angiotensinogen activation into angiotensin I
where do ARBs work?
at adrenal cortex to stop aldosterone release
