8.2.2: Pleuropneumonia Flashcards

1
Q

Pneumonia

A

Infection of the lower respiratory tract

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2
Q

Bronchopneumonia

A

Infection of the bronchi and parenchyma

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3
Q

Pleuropneumonia

A

infection of the lower respiratory tract that extends to the pleural space

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4
Q

What are the stages of pleuropneumonia?

A
  • Exudative stage - sterile transudate increased in the pleural space
  • Fibrinopurulent stage - bacterial invasion and fibrin deposition
  • Organisation stage - fibroblasts grow into the exudate (pleural peel)
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5
Q

What pathogens might be involved in pneumonia in horses?

A
  • Streptococcus equi subsp. Zooepidemicus = most common
  • Staphylcoccus aureus, Staph pneumoniae
  • Actinobacillus spp. (gram -ve non-enteric)
  • Escherichia coli, Pasteurella spp., Enterobacter spp., Klebsiella spp., Bordetella bronchiseptica
  • Bacteriodes fragilis
  • Fusobatcerium and Peptostreptococcus anaerobius
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6
Q

Clinical signs of pneumonia

A
  • Tachycardia/ tachypnoea
  • Respiratory distress
  • Fever
  • Anorexia
  • Depression
  • ± nasal discharge
  • Exercise intolerance
  • Crackles and dull areas on auscultation
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7
Q

Clinical signs more specific to pleuropneumonia

A
  • Pain in the intercostal space
  • Reluctance to walk, colic
  • Grunting during respiration
  • Abduction of elbows
  • Ventral oedema
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8
Q

Lung sounds suggestive of pneumonia/ pleuropneumonia

A
  • Crackles and wheezes
  • Dull areas
  • Dull area following a flat line (pleuropneumonia)
  • Pleural rubs (pleuropneumonia)
  • Radiation of cardiac sounds to areas well outside the typical areas (this occurs when there is lots of fluid/ pleural consolidation around the heart)
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9
Q

Diagnosis of pneumonia/ pleuropneumonia

A
  • Suspicion based on physical exam and rebreathing bag
  • Haematology and biochemistry
  • Endoscopy
  • Trans-tracheal wash and BAL
  • Thoracic ultrasound
  • Thoracic radiography
  • Thoracocentesis
  • Thoracoscopy
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10
Q

Clinical pathological findings with pneumonia

A
  • Neutrophilic leukocytosis
  • Leukopaenia
  • Anaemia (seen in chronic cases)
  • Increased fibrinogen and SAA (= systemic inflammation)
  • Decreased Fe2+
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11
Q

Discuss the use of TTW for suspected pneumonia

A

Trans-tracheal wash
* Extremely useful in suspected pneumonia
* Culture and sensitivity - best if percutaneous TTW; can do aerobic and anaerobic culture, if so do not fridge anaerobes
* Can get cytology representation of both lungs
* Obtain this even if pleural fluid is also available for culture
* Consider the impact of concurrent antibiotics the horse might be on

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12
Q

What might you see on endoscopy of a horse with pneumonia? What might this look like?

A
  • Might see lots of mucus - this is characteristic of bacterial pneumonia, equine asthma.
  • With a long endoscope, can try to identify the affected side/bronchi; and can see if there is an abscess draining into a bronchus
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13
Q

Describe the findings on this thoracic ultrasound, including the structures 1 and 2

A

1 - intercostal muscles
2 - pleural and lung surface
There is a defect in the pleura with comet tail below it - this could be pathology, or just an older horse.

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14
Q

Describe the findings on this thoracic ultrasound.

A

Several areas of pulmonary consolidation

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15
Q

Ultrasound is best for imaging which areas of the lungs?

A

The lung periphery/surface and pleura. If there is anything further in, might not be able to reach and image.

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16
Q

Describe the findings on this thoracic ultrasound.

A
  • This lung is consolidated - we can see further medially than the pleura, which is unusual.
  • Can see full thickness of the tip of the lung (not normal!)
  • A small amount of gas in the lung creates a hyperechoic artefact.
17
Q

Describe the findings on this thoracic ultrasound.

A

There is consolidated lung without air in it.

18
Q

What might you see on thoracic ultrasound if there was free fluid in the thoracic cavity? e.g. in a pleuropneumonia

A
  • Might see tip of lung floating in fluid
  • Might see fibrin floating in the pleural cavity
  • In early stage pleuropneumonia, these bits of floating fibrin and debris will be smaller
  • In later stage pleuropneumonia, there may be free fluid in the pleural cavity and more organised fibrin
19
Q

You want to take thoracic radiographs of a horse. Should you evacuate fluid from the thorax a) before or b) after you take the radiographs?

A

a) Before - this will allow you to better visualise structures

20
Q

Describe the lung pattern and pathology on these radiographs

A
  • Bronchoalveolar lung pattern
  • There is a fluid line visible
  • This is a horse with pleuropneumonia
21
Q

Describe the lung pattern shown here

A

Multinodular bronchoalveolar pattern

22
Q

Describe the pathology shown here

A

This is a horse with a pulmonary abscess

23
Q

First line antibiotics for pneumonia

A
  • Penicillin + gentamicin IV
  • Penicillin + Gentamicin + Metronidazole (to provide anaerobe cover e.g. aspiration pneumonia)

Adjustments should be made based on culture and sensitivity

24
Q

What inhaled antibiotics could we use in horse?

A
  • Gentamicin
  • Ceftiofur
  • Cefquinome

These antibiotics are licensed in horses but may not be licensed for the inhaled route.

25
Q

Describe how to perform a thoracocentesis in the horse

A
  1. Identify site for drain with ultrasound
  2. Avoid the thoracic vein - level of the olecranon, slightly further dorsal
  3. ICS 7-8 ventrally, close to costochondral junction
  4. Clip, prep aseptically, sedate.
  5. Give local anaesthesia SC
  6. Stab incision at cranial edge of rib
  7. Advance drain and feel the pop
  8. Withdraw trochar and advnce blunt tube
  9. Secure with Chinese finger trap suture (Heimlich valve)
26
Q

Diagnostic value of thoracicentesis

A
  • Cytology
  • Culture and sensitivity
27
Q

Therapeutic value of thoracocentesis

A
  • Drain proinflammatory products
  • Remove bacteria
  • Help decrease adhesion formation
  • Respiratory function improvement
28
Q

Risk factors for pneumonia

A
  • After viral infections
  • Strenuous exercise
  • Transportation and elevation of the head
  • General anaesthesia
  • Overcrowding and inclement weather
  • Dysphagia -> aspiration
29
Q

Risk factors for pleuropnuemonia

A

Long distance transportation
* Believed to be assocated with head elevation for long period of time

30
Q

Risk factors for aspiration pneumonia

A
  • Dysphagia: pharyngeal and post-pharyngeal
  • Oesophageal obstruction
  • General anaesthesia
  • Cleft palate
31
Q

True/false: pneumonia in horses will progress rapidly if untreated.

A

True

32
Q

When should you refer a horse with pneumonia?

A
  • If no initial response to antibiotics
  • If systemic/ respiratory compromise
  • If intensive care is required
33
Q

When should you perform culture and sensivity in horses with pneumonia?

A

Always.
* Ideally perform TTW and sample pleural effusion
* Include anaerobic coverage