Tricyclic antidepressants Flashcards

1
Q

MOA of tricyclic antidepressants?

A

-blocks the reuptake of monoamines
- mainly noradrenaline and 5 HT into presynaptic terminals

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2
Q

side effects of TCA?

A
  • anticholingeric
    1- blurred vision
    2- dry mouth
    3- constipation
    4- urinary retention
  • sedation
  • weight gain
  • cardiovascular
    1- postural HTN
    2- tachycardia
    3- arrhythmias
    4- cardiotoxic in overdose
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3
Q

examples of TCA?

A
  • imipramine
  • dosulepin
  • amitriptyline
  • lofepramine
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