13.2 Cell Cycle Control III

Question 1

All “factors” that act thro the MAP kinase pathway or the MAPK pathway are considered _______ (in this course).

Answer 1

Mitogens

Question 2

One of the major targets for the MAP kinase pathway is the gene that encodes the protein _______.

Answer 2

myc

Question 3

Myc gene

Answer 3

Causes myelocytomatosis….a cancer caused by uncontrolled growth of B lymphocytes. Also known as lymphoma.

Question 4

Myc controls the expression of _________ .

Answer 4

Cyclin G1

Also, DNA regulate the p53 signaling pathway

Question 5

Cell cycle is regulated by signaling factors affecting cell division which are called _______.

Answer 5

Mitogens

Question 6

Cell cycle is regulated by signaling factors that affect cell growth which are called __________ .

Answer 6

Growth factors

Question 7

G1-Cdk regulates function of ______ and the expression of ____ and _______.

Answer 7

Rb

G1 and S-cyclins

Question 8

What controls cell cycle checkpoints?

Answer 8

p53

Regulates the expression of proteins that inhibit the cell cycle. Under normal conditions, p53 is not highly expressed

Question 9

Mdm2

Answer 9

Targets p53 for degradation

Question 10

What blocks the cell cycle from progression thro p53/p21?

Answer 10

DNA damage

Question 11

About half of all human cancers, in addition to an initial mutation also have mutations in the ______.

Answer 11

p53 gene which prevents uncontrolled cell division

Question 12

TOR or mTOR (mammalian version) regulates ________ ?

Answer 12

Cell growth

Question 13

MADs regulate ________ in the cell cycle?

Answer 13

The Metaphase/anaphase transition checkpoint