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PED2006 - Systems Pharmacology > Adrenal Hormomes [14] > Flashcards

Adrenal Hormomes [14] Flashcards

1
Q

What bit of the adrenal gland makes aldosterone

A

Zona glomerulosa

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2
Q

What bit of the adrenal gland makes cortisol

A

Zona fasiculata

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3
Q

What bit of the adrenal gland makes androgens

A

Zona reticularis

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4
Q

Cortisol is for …

A

Sleep / wake cycle

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5
Q

Mineral corticoids are for …

A

Na / K regulation

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6
Q

Steroid hormone receptor signalling (4 steps)

A
  1. Diffuses across membrane
  2. Binds intracellular receptor - translocation to nulceus
  3. Activated receptor binds target gene response element in DNA
  4. Modulates txn of specific gene
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7
Q

What effects does aldosterone have on Na and K

A

Increase Na reabsorption in DCT
Increase K secretion in urine

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8
Q

What stimulates aldosterone

A

Low Na
High K
Angiotensin II

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9
Q

Cause of hyperaldosteronism x2

A

Conns syndrome
Tumour in z glomerulosa

Or

Low BP - high renin - excess aldosterone

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10
Q

Where does aldosterone bind

A

MR receptor on nucleus

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11
Q

Treatments for hyperaldosteronism

A

MR antagonist
Spirinolactone

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12
Q

Cause of hypoaldosteronism x2

A

Addisons disease
Destruction of z glomerulosa

Or

Renin deficiency

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13
Q

Treatment of hypoaldosteronism

A

MR agonist
Fludrocortisone

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14
Q

Cortisol increases …

A

Glucose in the bloodstream

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15
Q

What does cortisol do in the liver

A

Inc glucose production

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16
Q

What does cortisol do in the pancreas

A

Inhibit insulin release

17
Q

What does cortisol do in muscle

A

Inc protein degradation
Inc aa for gluconeogenesis

18
Q

What does cortisol do in the adipose

A

Inc lypolysis
Inc fatty acid & glycerol for gluconeogenesis

19
Q

Cortisol levels are highest in the …. And is released in response to ….

A

Morning
Stress

20
Q

How does cortisol have an anti inflammatory effect

A

Induces lipocortin
Inhibiting phospholipids A2
Decr in inflammatory mediators (leukotrienes)

21
Q

How is cortisol released

A

Hypothalamus - corticotropin releasing hormone
Pituitary - adrenocorticotropic hormone
Adrenal - cortisol

22
Q

How does cortisol have immunosuppressive effects

A

Binds NF-kB so it cant bind nucleus
Also
Promotes lkBa synthesis (NF-kB inhibitor)

23
Q

What’s is cushings disease

A

Hypercortisolaemia
Tumour on a fasiculata
Moon face
Poor wound healing

24
Q

Treatment for Cushings

A

Metyrapone
11 beta hydroxylase inhibitor
(Last enzyme in cortisol production)

PED2006 - Systems Pharmacology (19 decks)

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