Glucocorticoid Adverse Reactions Flashcards
fluid and electrolyte disturbances
-sodium and fluid retention
-potassium loss
-hypokalemic alkalosis
-hypertension
-hypocalcemia
-hypotension
-shocklike reactions
musculoskeletal disturbances
-muscle weakness
-loss of muscle mass
-tendon rupture
-osteoporosis
-aseptic necrosis of femoral or humeral heads
-spontaneous fractures
cardiovascular disturbances
-thromboembolism
-fat embolism
-thrombophlebitis
-necrotizing angiitis
-syncopal episodes
-cardiac arrhythmias
-aggravation of hypertension
-fatal cardiac arrhythmias (rapid high dose IV methylprednisone)
-heart failure
GI disturbances
-pancreatitis
-abdominal distention
-ulcerative esophagitis
-N/V
-increased appetite
-weight gain
-peptic ulcer or bowel perforation
-hemorrhage
dermatological disturbances
-impaired wound healing
-thin fragile skin
-petechiae
-ecchymoses
-erythema
-increased sweating
-suppression of skin test reactions
-subcut fat atrophy
-purpura
-striae
-hirsutism
-acneiform eruptions
-urticaria
-angioneurotic edema
-perineal itch
neurological disturbances
-convulsions
-increased intracranial pressure with palledema (usually after tx is stopped)
-vertigo
-headache
-neuritis or paresthesia
-steroid psychosis
-insomnia
endocrine disturbances
-amenorrhea
-menstrual irregularities
-cushingoid state
-suppression of growth in children
-secondary adrenocortical and pituitary unresponsive
-decreased CHO tolerance
-latent DM
-increased requirements for insulin or oral hypoglycemic in DM clients
ophthalmic disturbances
-posterior subcapsular cataracts
-increased intraocular pressure
-glaucoma
-exophthalmos
metabolic disturbances
-negative nitrogen balance (caused by protein catabolism)
other disturbances
-anaphylactic or hypersensitivity reactions
-aggravation of existing infections
-malaise
-increase or decrease in sperm motility and number
