Jaundice Flashcards
Hyperbilirubinemia characterized by yellow discoloration of the skin, sclera and mucus membranes
Jaundice
Visible Jaundice - TB =
≥3.0-5.0 mg/dL or higher
Overt Jaundice
1.0-1.5 mg/dL (no observable signs)
more commonly termed for serum or plasma with yellow discoloration due to hyperbilirubinemia
Icterus/Ictericia
Also known as hemolytic jaundice/unconjugated hyperbilirubinemia
Pre-hepatic Jaundice
- Caused by too much red blood cell destruction
- Hemolytic disease of the newborn
- Hemolytic anemia
- Malaria
Pre-hepatic Jaundice
Laboratory findings: Pre-hepatic Jaundice
o Indirect bilirubin:
o Direct Bilirubin:
o Urobilinogen:
o Urine bilirubin:
o Indirect bilirubin: Increased (toxic and might cross the blood brain barrier → kernicterus → motor dysfunction and retardation)
o Direct Bilirubin: Normal
o Urobilinogen: Normal
o Urine bilirubin: Negative
Also known as Obstructive jaundice
Post-hepatic Jaundice
Caused by failure of bile to flow to the intestine or impaired bilirubin excretion
Post-hepatic Jaundice
Laboratory findings: Post-hepatic Jaundice
o Indirect bilirubin:
o Direct bilirubin:
o Urobilinogen:
o Urine bilirubin:
o Alkaline phosphatase:
o Indirect bilirubin: Normal
o Direct bilirubin: Increased
o Urobilinogen: Decreased
o Urine bilirubin: Positive (can be excreted in the urine)
o Alkaline phosphatase: Increased
T/F. ALP is the number one marker for obstructive or post-hepatic obstruction
True
High ALP excretion rate due to
obstruction
Hepatocellular combined jaundice
Hepatic Jaundice
Caused by disorders of bilirubin metabolism, transport defects, hepatocellular injury or destruction
Hepatic Jaundice
Most commonly caused by inherited disorders
Hepatic Jaundice
