Morphine

Question 1

Brand Names

Answer 1

MS-Contin, Astramorph, Depodur, Duramorph

Question 2

Drug Classification

Answer 2

Opioid Analgesic

Question 3

Mechanism of Action

Question 4

Indications

Answer 4

Moderate to severe pain

Question 5

Contraindications

Answer 5

Hypersensitivity, SBP <100mmHg, patient with non-opioid directive

Question 6

Side effects / Precautions

Answer 6

itchy skin, nausea, vomiting, headache, constipation, somnolence

Question 7

Adult Dose

Answer 7

Pain relief: 0.1 mg/kg IV/IO/IM (single max dose of 10 mg); May
repeat every 5 minutes to a total of 20 mg titrated to pain relief

Acute Coronary Syndrome: 0.1 mg/kg IV/IO/IM (up to 5 mg); May repeat every 5 minutes to a maximum of 15 mg titrated to pain relief

Intubation: 2-5 mg, slow IV/IO push (be cautious of hypotension), repeat every 5 - 10 minutes as needed

Post-Airway: 0.1 mg/kg (max 5 mg), slow IV/IO push (be cautious of hypotension), repeat every 5- 10 minutes as needed

Question 8

Pediatric Dose

Answer 8

Pain relief: Morphine 0.1 mg/kg IV/IO (maximum dose 5 mg) may repeat 0.05 mg/kg (maximum dose 2.5 mg) every 5 minutes to a total of 3 doses

Question 9

Max adult dose (Max pedi dose)

Answer 9

20 mg total (10 mg total)

Question 10

Onset of action

Answer 10

IV: <5 minutes, IM: 5-20 minutes

Question 11

Duration of Effects

Answer 11

IV: 2-4 hours, IM: 4-6 hours

Question 12

Method of Administration

Answer 12

IV/IO, IM