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Pharmaceutics > Compactability > Flashcards

Compactability Flashcards

1
Q

Compression

A

Pressure is applied forcing particles into close proximity reducing porosity and volume

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2
Q

Porosity

A

having holes in its structure

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3
Q

Compressibility

A

the amenability of a substance to compression

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4
Q

Compaction

A

When pressure is applied Particles causing them to cohere to form a solid of a specific shape

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5
Q

Compatibility

A

Susceptibility to compaction

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6
Q

Densification

A

Increasing the Density of something

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7
Q

Elastic deformation of shape

A

Densification of a product due to compression however once force is removed, the product returns to its original shape

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8
Q

Examples of compounds that undergo elastic deformation of shape

A

Acetyl salicylic and starch

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9
Q

What are the two types of particle deformation

A

elastic deformation of shape and plastic deformation of shape

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10
Q

Plastic deformation of shape

A

Force and heat is applied to a product permanently altering its shape. Occurs due to molecules slide over each other. Occurs once the elastic limit has been reached

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11
Q

Examples of compounds that undergo plastic deformation of shape

A

Sodium chloride and sodium bicarbonate

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12
Q

What does the compression force determine

A

Tablet volume , porosity, density and tensile strength

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13
Q

What does the compression force determine

A

Tablet volume , porosity, density and tensile strength

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14
Q

What is responsible for the the 1st phase of the particle deformation graph

A

particle rearrangement and fragmentation

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15
Q

What is responsible for the the 2nd phase of the particle deformation graph

A

Elastic and plastic deformation of shape

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16
Q

What is responsible for the the 3rd phase of the particle deformation graph

A

Elastic deformation of compact

17
Q

What is the 1st phase of the tensile strength graph

A

Compression but no compact

18
Q

What is the 2nd phase of the tensile strength graph

A

Higher compression increases the tensile strength

19
Q

What is the 3rd phase of the tensile strength graph

A

Maximum tensile strength reached

20
Q

Why does tensile strength occur

A

Due to inter particle bonding within the tablet

Pharmaceutics (7 decks)

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