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604 > Drug induced derm > Flashcards

Drug induced derm Flashcards

1
Q

4 categories of DID

A

Exanthematous
Uticarial
Blistering
Pustular

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2
Q

Exanthematous

A

Maculopapular eruption vs Dress

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3
Q

Uticarial

A

Angioedema vs serum sickness-like

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4
Q

Blistering

A

Fixed drug eruption vs SJS/TEN

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5
Q

Pustular

A

Acneiform vs AGEP

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6
Q

Dress duration

A

Onset 1-6 weeks
Resolve 6-8 weeks

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7
Q

Maculopapular eruption duration

A

onset 7-10 days
resolve 7-14 days

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8
Q

Uticarial angioedema duration

A

mins-hr

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9
Q

Serum sickness-like duration

A

onset 1-3 weeks
resolve 1-2 weeks

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10
Q

Fixed drug eruption duration

A

onset mins-days
resolve days

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11
Q

SJS/TEN duration

A

onset 7-15 days

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12
Q

AGEP duration

A

onset <3 days

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13
Q

Drugs- DRESS

A

“SAAD”
Sulfa
Allopurinol
Anticonvulsants
Dapsone (sulfa)

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14
Q

Drugs – SJS/TEN

A

“SPAAN”
Sulfa
Penicillins
Allopurinol
Anticonvulsants
NSAID “-cams”

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15
Q

HLAB58:01

A

Allopurinol, asian ethnicity

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16
Q

HLAB*1502

A

carbamazepine, phenytoin, phenobarbital, asian ethnicity

17
Q

Dress

A

t cell activation
errpution + fever
>50% BSA

18
Q

Allopurinol and risk for DRESS

A

excess dose
renal dysfunction
thiazide use, HTN
asian

19
Q

Renal dosing for allopurinol

A

1.5 mg x eGFR (ml/min)

20
Q

Dress Tx

A

Organs? liver, kidney, lung
Y = Systemic steroids (0.5-2mg/kg/day)
N= topical steroids (high potency)

21
Q

High potency steroids

A

Triamcinolone 0.5
Fluocinonide
Betamethasone 0.05
Fluocinonide/halicinonide

22
Q

Low potency steroids

A

Hydrocortisone
Desonide
Triamcinolone 0.025
Betametasone VALERATE 0.1
dexamethasone??

23
Q

SJS/TEN

A

acute mucocutaneous, cytotoxic T cell activation
- keratinocyte apoptosis (granulysin/fas ligand)
- painful bullous formation + fever

24
Q

Risk for developing SJS/TEN

A

HIV infection
Lupus (SLE)
Malignancy
Uv light/radiation
HLAB1502

25
Q

Maculopapular

A

most common
presents as a RASH

26
Q

Uticarial angioedema

A

Type 1 hypersensitivty
IgE mediated
HIVES

27
Q

Fixed drug erruption

A

blisters that re-occur in the same place

28
Q

Drug cross reactivity

A

very minimal between sulfa vs sulfa abx

29
Q

Sulfa meds

A

loop diuretic, thiazide, sulfasalazine,

30
Q

crossreactivity of PCN and Ceph

A

1-2%
based on R1 side chain

604 (18 decks)

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