MOA

Question 1

Saturated solution of potassium idodine (SSKI)

Answer 1

temporarily inhibits secretion of the thyroid hormones, effect will not be maintained

Question 2

Propylthiouracil (PTU)

Answer 2

Thionamide

inhibits the synthesis of thyroid hormones by blocking oxidation of iodine, inhibits peripheral conversion of T4 to T3

Question 3

methimazole

Answer 3

Thionamide

inhibits the synthesis of thyroid hormones by blocking oxidation of iodine, inhibits peripheral conversion of T4 to T3

Question 4

Levoxyl

Answer 4

Levothyroxine (T4)
Is a thryoid hormone

**Drug interactions = PPIs, antacids, sevelamer, sucralfate (Al, Mg, Ca, multivitamins)
**beta blockers, amiodarone, PTU, and steroids will decrease the effectiveness of levothyroxine
**estrogen, SSRI, hepatic inducers will decrease thyroid hormones

HIGHLY protein bound > 99%

may increase warfarin efficacy (increase INR)