Test 2: Benzylisoquinolones Flashcards
What is the structure of Atracurium?
Quaternary
What is the intubating and maintenance dose of Atracurium?
I: 0.5 mg/kg
M: 0.1 mg/kg
What is the onset of Atracurium?
2-3 minutes
What is the duration of action of Atracurium?
20-60 minutes
What is the ED95 of Atracurium?
0.2 - 0.25 mg/kg
How is Atracurium Metabolized/Excreted?
-2/3 by spontaneous ester hydrolysis by nonspecific esterases
-1/3 by Hoffman Elimination
-82% protein bound
-Metabolites are secreted in the bile/urine
-Dose dependent increases in DOA
What are the side effects of Atracurium?
-Dose-dependent histamine release
-May cause transient drop in SVR and increase in CI
-Severe bronchospasm
-Laudanosine toxicity
What are the Misc effects of Atracurium?
-Prolonged by hypothermia and acidosis
-Precipitates with alkaline solutions
-Decrease dose in neonates by half (!)
-Better choice for maintenance than for induction
What is the structure of Cisatracurium?
-Quaternary
-3-4 x’s as potent as Atracurium
-5x’s as potent as Rocuronium
What is the intubating dose of Cisatracurium?
I: 0.1 - 0.5 mg/kg
What is the onset of Cisatracurium?
2 - 4 minutes
What is the duration of action of Cisatracurium?
40 - 75 minutes
What is the ED95 of Cisatracurium?
0.05 mg/kg
What is the metabolism/excretion of Cisatracurium?
-2/3 by Hoffman Elimination
-1/3 by Ester Hydrolysis by non specific tissue esterases.
-Isomer of Atracurium
What are the side effects associated with Cisatracurium?
-Laudanosine toxicity (5x less than Atracurium)
