Hepatitis C

Question 1

Pathophysiology of Hepatitis C

Answer 1

RNA Flavivirus
Incubation 6-9 Weeks
Risk: IV Drug Users and Blood Transfusion <1991

Needle Stick Transmission or Mother to Child but Breastfeeding Fine
No Vaccine

Features
- Transient rise in serum aminotransferases and jaundice
- fatigue
-arthralgia

Investigate
- HCV RNA

Risk of Chronic Hep C
- Rheumatology
- Sjogren
- Cirrhosis
- Hepatocellular Cancer
- Cryoglobuniaemia

Treat
- Protease Inhibitors

Question 2

Ribavirin Side Effects

Answer 2

Haemolytic Anaemia
Cough
No Preg within 6 Months of Stopping

Question 3

Interferon Alpha Side Effects

Answer 3

Flu Like
Depression
Fatigue
Leukopenia
Thrombocytopenia