antiplatelet/Fibrinolytic

Question 1

Aspirin mechanism of action

Answer 1

irreversibly inhibits COX-1
inhibits the synthesis of TXA2
Platelets dont contain DNA/RNA so cant synthesis new COX-1
Irreversibly inhibtis and last the life span (7-10)

Question 2

what are aspirin’s adverse effects

Answer 2

abdominal/stomach pain/cramping
black tarry stool, bloody/cloudy urine
chest pains
convulsions
difficulty breathing

Question 3

when is Aspirin perscribed

Answer 3

prophylactically to prevent arterial thrombosis
-Transiet ischaemic attack
-stroke
-myocardial infarction

Question 4

when is aspirin not suitable

Answer 4

-people with allergies to ibuprofen
-asthma patients
-patients with peptic ulcers or gastritis

Question 5

Name an example of a fibrinolytic

Answer 5

streptokinase or alteplase

Question 6

Name an example of a fibrinolytic

Answer 6

streptokinase or alteplase

Question 7

how does alteplase work ?

Answer 7

activates conversions of plasminogen to plasmin which breaks down fibrin
this dissolves clots
these clots can cause strokes

Question 8

when is alteplase not suitable to be used

Answer 8

if a patients has any haemorrhage or serious head trauma within last 3 months

Question 9

what is the main adverse effects of alteplase

Answer 9

Bleeding - haemorragic stokes

Question 10

when is alteplase administered

Answer 10

when a transiet ischaemic attacks occurs