Oncogenes

Question 1

What are oncogenes ?

Answer 1

cancer promoting genes

cancer promoting genes that are derived from normal genes (proto-oncogenes)

Question 2

Proto-oncogenes may become oncogenes via the following processes:

Answer 2

Mutation (point mutation)
Chromosomal translocation
Increased protein expression

Question 3

Which oncogene is related to CML

Answer 3

ABL

Question 4

Which oncogene is related to Burkitt lymphoma ?

Answer 4

c-MYC

Question 5

Which oncogene is related to Neuroblastoma?

Answer 5

n-MYC

Question 6

BCL-2 oncogene is related to what cancer ?

Answer 6

Follicular lymphoma

Question 7

Multiple endocrine neoplasia (types II and III)

Answer 7

RET

Question 8

Many cancers especially pancreatic is related to what oncogene ?

Answer 8

RAS

Question 9

Breast and ovarian cancer is related to what oncogene ?

Answer 9

erb-B2 (HER2/neu)

Question 10

how are oncogenes different from tumor suppressor genes ?

Answer 10

restrict or repress cellular proliferation in normal cells

inactivation through mutation or germ line incorporation is implicated in renal, colonic, breast, bladder and many other cancers

Question 11

best known tumour suppressor genes is?

Answer 11

p53 gene offers protection by causing apoptosis of damaged cells

BRCA 1 and 2