Poop Drugs

Question 1

Bulk forming laxative

Answer 1

Binds luminal water to decreased consistency of stool

Fiber

Question 2

Osmotic laxative

Answer 2

draws water into lumen (electrolyte imbalance)

polyethylene glycol
mg hydroxide
lactulose

Question 3

Surfactant

Answer 3

decrease stool surface tension + soften stool (adds water)

docusate

Question 4

Stimulant laxative

Answer 4

stimulate peristalsis – myenteric plexus stimi

bisacodyl
senna

Question 5

Chloride channel agonist

Answer 5

Cl- efflux w/ Na+ H2O to follow

Lubiprostone

Question 6

Peripheral mu-opioid receptor ANTAGONIST

Answer 6

causes peristalsis
methylnaltrexone

Question 7

Peripheral Opioid agonist

Answer 7

Mu in colonic myenteric plexus = slow peristalsis

loperamide
diphenoxylate w/ atropine + tincture of opium

Question 8

Bulk forming

Answer 8

absorbs water + contents to form stool

Psyllium
pectin

Question 9

Bismuth subsalicylate

Answer 9

stimulates fluid absorption
inhibits prostaglandin synthesis (no spasms)

Question 10

Somatostatin analog

Answer 10

reduces secretions (pancreas + GI hormones)

Octreotide

Question 11

Bile acid sequestrants

Answer 11

bind Bile Acid in intestines

cholestyramine