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QC LAB Flashcards

1
Q

Used almost exclusively with alternative detection such as mass spectrometry.

A

Capillary columns

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2
Q

Which is not a possible sample material/s for IR Moisture Analyzer?

A

Gas

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3
Q

An instrument used to measure angle of rotation cause by passing of polarized light through and optically active substance.

A

Polarimeter

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4
Q

Which among the following physical properties is used in assessing the purity of a volatile oil?

A

Refractive index

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5
Q

A method of water determination which do not distinguish weight loss due to vaporization of water from other volatile compounds

A

Thermogravimetric

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6
Q

It is often used for determining the moisture content of drugs that have low water contents.

A

Oven Drying

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7
Q

Measurement of internal diameter is less than 0.3 mm.

A

Capillary columns

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8
Q

Which is (are) a part (s) of a HPLC apparatus?

I. HPLC pumping system
II. Chromatographic columns
III. Injector port
IV. Detectors (UV/ Vis)

A

I, II, III, IV

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9
Q

This is a simple way to check for the acidity/alkalinity of the sample and very useful when all you need is 0.2-0.5pH unit accuracy.

A

pH strip

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10
Q

Ca carbide method is classified as:

A

Chemical

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11
Q

It is used to observe both the total reflection borderline and the instrument’s internal measurement.

A

eyepiece

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12
Q

IR 35 moisture analyzer is classified as:

A

Thermogravimetric

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13
Q

In the formula of specific rotation, what is being measured in the “l”.

A

Sample tube

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14
Q

A binder is added to ensure that the stationary phase adheres firmly to the backing plate and does not flake off during the development.

A

True

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15
Q

A liquid/gas phase, maybe pure/mixture of liquids or a gas vapor; carries the sample.

A

Mobile phase

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16
Q

A compound that is capable of rotating a plane-polarized light is:

A

Optically active

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17
Q

A method of water determination in which the solid must dissolve in the titration medium to be sure that the total amount of moisture is released.

A

Chemical

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18
Q

Halogen drying is classified as what specific water/moisture determination method?

A

Thermogravimetric

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19
Q

Silica gel it is best suited to the analysis of acidic compounds and polar compounds such as amino acids and sugars.

A

True

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20
Q

A method of water determination which is applied to most systems with a moisture content of >0.1%

A

Thermogravimetric

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21
Q

Pans should be dried in an oven and stored in a desiccator prior to use.

A

True

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22
Q

A dextroratory optically active compound tend to rotate plane polarized light clockwise and correspond to a value that is;

A

Positivr

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23
Q

Type of column that is used to improved sensitivity and lower solvent consumption at the expense of loading capacity.

A

Low-ID columns

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24
Q

Which part of the polarimeter allows the entry of plane polarized light?

A

Polarizer

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25
Q

Azeotropic-toluene distillation is under what USP method of water determination.

A

Method II

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26
Q

A technique that is used to separate mixtures of substances into their components.

A

Chromatography

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27
Q

Which of the following is NOT a method used in determining moisture content?

A

Trituration method

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28
Q

For one-point calibration, this standard buffer solution can be used:

A

pH 7

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29
Q

Part of the HPLC that provide the higher pressure required to move the mobile phase and analyte through the densely packed column.

A

Pump

30
Q

Detector setting of HPLC:

A

280 nm

31
Q

A support for adsorbent layer in TLC plate must be an inert material. Which among the choices is not used as one?

A

Piece of wood

32
Q

It is a bench-top device for the high-precision measurement of an index of refraction.

A

Refractometer

33
Q

Measurement of internal diameter is 4.6mm.

A

Analytical scale columns

34
Q

This method is applied to most systems with a moisture content of >0.1%.

A

Thermogravimetric

35
Q

The hydrogen ion concentration may be expressed in terms of _____.

A

pH

36
Q

Pans should be handled with forceps because fingerprints can contribute to the mass of a sample.

A

True

37
Q

Involves the spotting of a sample of a mixture of components at one end of an adsorbent-coated glass plate followed by a passage of a solvent through the adsorbent for the purpose of separating the components of the sample.

A

Thin Layer chromatography

38
Q

Measurement and interpretation of the polarization of transverse waves.

A

Polarimetry

39
Q

When the direction of the rotation of optically active substance in polarimeter is towards the left, it is known as _

A

Levorotatory

40
Q

Part of the refractometer that contains the measuring prism and acts as sample compartment.

A

lower prism

41
Q

It is an instrument that is used to measure the humidity.

A

Electrolytic Hygrometer

42
Q

An electronic device for potentiometric measurements

A

pH meter

43
Q

In this instrument the liquid sample is sandwiched into a thin layer between an illuminating and refracting prism.

A

Abbe Refractometer

44
Q

Scientific instrument used to measure the angle of rotation caused by passing polarized light through an optically active substance.

A

Polarimeter

45
Q

Csaba Horvath was one of the pioneers of this instrument.

A

HPLC

46
Q

olvent or solvent mixture is drawn up the plate via capillary action.

A

TLC

47
Q

Crushing strength of tablets

A

Hardness tester

48
Q

Thickness and diameter of tablets

A

Vernier caliper

49
Q

Optical activity of sugars

A

Polarimeter

50
Q

Index of refraction of volatile oils

A

Refractometer

51
Q

Acidity and basicity of liquid pharmaceuticals

A

pH meter

52
Q

Water content of excipients

A

Moisture analyzer

53
Q

Amount of drug absorbed

A

Dissolution tester

54
Q

Amount of acid radical impurities

A

UV-Vis spectrophotomer

55
Q

Time to break tablets into smaller pieces

A

Disintegration tester

56
Q

Abrasion to shock of tablets

A

Friabilator

57
Q

stationary phase is a polymeric substance containing numerous pores of molecular dimensions.

A

Size Exclusion

58
Q

stationary phase is liquid

A

Partition chromatography

59
Q

stationary phase is a polymeric matrix on which functional group bonded.

A

Ion exchange

60
Q

stationary phase is solid.

A

Adsorption chromatography

61
Q

Sample: Aspirin 80 mg tablets
Specification = 90-110%
Concentration of Aspirin std = 0.020 mg/mL
Volume of sample taken = 15 μL Peak area of the standard = 685676 Peak area of the sample = 421232
Compute for the mg of Aspirin (2 dec places) = ?

A

81.91 mg

% Labeled claim = 102.39%

QC disposition (passed or failed): passed

62
Q

Compute for the specific rotation:
50 grams of lactose dissolved in 100 mL distilled water & was put in a 100-mm polarimeter tube. The reading is 26.9203°.
Round off your answer in to 4 decimal places. Units must be in word.

A

53.8406 degrees

63
Q

Compute for the observed angle of rotation (round off to 4 decimal places), Unit must be in word.
Given: [α]λT = - 29.3301° concentration = 30g dissolved in 100mL of distilled water
length of tube = 200mm

A

-17.5981 degrees

64
Q

A 3,068 mg of Phenobarbital was dried in an oven at 150 degree Celcius. After 4 hours, the weight decreased to 46.68 grains. Compute for the % moisture content of Phenobarbital. What will be the QC disposition if the limit is not more than 7.0% of its weight.

Note: to achieve a uniform answer, convert mg to grains by using the whole number conversion, but the answer of the conversion must be in 4 decimal places. Recall the conversion introduce during your Pharmaceutical Calculation course.

A

1.10%

65
Q

A 3,068 mg of Phenobarbital was dried in an oven at 150 degree Celcius. After 4 hours, the weight decreased to 46.68 grains. Compute for the % moisture content of Phenobarbital. What will be the QC disposition if the limit is not more than 7.0% of its weight.

A

PASSED

66
Q

Compute for the pH and pOH of 0.0028M Nitric acid Note: round off both answers up to 4 decimal places.

A

pH 2.5528

pOH 11.4472

67
Q

A 15 grams Hyoscine was weighed to make 50mL solution. It was placed in a 100mm sample tube. Compute for the observed angle of rotation of hyoscine if the specific rotation is +12.85 degrees.

A

3.855 degrees

68
Q

The water content of Meropenem powder using 0.0123 grams sample was computed at 5.18%. If the volume of the reagent used reached 13.85m L, what is the water equivalence factor of the Karl Fischer reagent ?

A

0.046

69
Q

A raw material sample of Rose oil was submitted to QC dept. for testing. The sample obtained an n27D reading (below) at 270C.
USP specification for Rose oil: N20D = according to the specifications given in your notes.

  1. Calculate the n20D of the oil.
  2. Based on the specifications previously given in your notes for
    rose oil, does it conform with the USP specification? (passed/failed)
A
  1. = 1.4852
  2. FAILED
70
Q

An acacia was placed in an oven and dried for one and a half hour. A 0.221 kgs final weight has resulted to a 0.95% moisture content. What is the initial weight (mg) of the excipient?

A

223119.64 mg

qc lab (2 decks)

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