Anticholinergics Flashcards

1
Q

Atropine: Class

A

Antimuscarinic

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2
Q

Atropine: Use

A

Symptomatic bradycardia
Treatment of Cholinergic Syndrome
Paired with Edrophonium in NMB reversal

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3
Q

Atropine: Mechanism of Action

A

Competitive antagonist of acetylcholine at muscarinic receptors

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4
Q

Atropine: Dose

A

7 mcg/kg with Edrophonium
ACLS: 1mg Bolus, MAX 3 mg

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5
Q

Atropine: Pharmacokinetics

A

Absorption: IV, IM, PO

Onset: 1 minute
Duration of Action: 1 hour

Metabolism: Hepatic

Excretion: Renal and Hepatic

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6
Q

Atropine: Contraindictions

A

CAD
Pheochromocytoma
Hyperthyroidism
Myasthenia Gravis

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7
Q

Atropine: Considerations

A

Causes tachycardia
Sedation (crosses blood brain barrier)
Anticholinergic Syndrome

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8
Q

Glycopyrrolate: Class

A

Antimuscarinic

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9
Q

Glycopyrrolate: Use

A

Secretions
Bradycardia
Paired with Neostigmine

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10
Q

Glycopyrrolate: Mechanism of Action

A

Competitive antagonist of acetylcholine at muscarinic receptors

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11
Q

Glycopyrrolate: Dose

A

Non symptomatic bradycardia: 0.1 - 0.2 mg
With Neostigmine: 0.2 mg/ 1 mg of Neostigmine

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12
Q

Glycopyrrolate: Pharmacokinetics

A

Absorption: IV, IM, PO

Onset: 2 minutes
Duration of Action: 2 hours

Metabolism: Liver

Excretion: Renally, unchanged

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13
Q

Glycopyrrolate: Contraindications

A

CAD
Pheochromocytoma
Hyperthyroidism
Myasthenia Gravis

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14
Q

Glycopyrrolate: Considerations

A

Tachycardia

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15
Q

Scopolamine: Class

A

Antimuscarinic

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16
Q

Scopolamine: Use

A

PONV
Sedation
Motion Sickness

17
Q

Scopolamine: Mechanism of Action

A

Competitive antagonist of acetylcholine at muscarinic receptors

18
Q

Scopolamine: Dose

A

Patch: 1.5mg

19
Q

Scopolamine: Pharmacokinetics

A

Absorption: Transdermal, IV

Onset: 4 hours
Duration of Action: 24 hours

Metabolism: Hepatic

Excretion: Renal and Hepatic

20
Q

Scopolamine: Contraindications

A

CAD
Pheochromocytoma
Hyperthyroidism
Myasthenia Gravis

21
Q

Scopolamine: Considerations

A

Tachycardia
Sedation
Anticholinergic Syndrome