Systemic sclerosis

Question 1

Systemic sclerosis is a condition of unknown aetiology characterised by

Answer 1

hardened, sclerotic skin and other connective tissues

Question 2

Limited cutaneous systemic sclerosis

Answer 2

Raynaud’s may be the first sign

scleroderma affects face and distal limbs predominately

associated with anti-centromere antibodies

Question 3

subtype of limited systemic sclerosis is CREST syndrome

Answer 3

Calcinosis,

Raynaud’s phenomenon,

oEsophageal dysmotility,

Sclerodactyly,

Telangiectasia

Question 4

Diffuse cutaneous systemic sclerosis

Answer 4

affects trunk and proximal limbs predominately

Question 5

Diffuse cutaneous systemic sclerosis associated with

Answer 5

anti scl-70 antibodies