Protein turnover Flashcards
1
Q
Describe the molecular events required for ubiquitin-dependent protein breakdown! Briefly, describe 3 examples how ubiquitin-dependent proteolysis regulate crucial cellular functions!
A
- Pages 5-7. , 10. ,19. , 44. in the lecture pdf
- Examples: cyclines, p53, HIF1-alpha, pages 11-15.
2
Q
Define the term autophagy and briefly, describe the molecular events required for autophagosome formation!
A
What is autophagy, types of autophagy, autophagosome formation,
3
Q
What is the role of autophagy in starvation? How organelles are targeted into the autophagosome during selective autophagy?
A
Autophagy in heart, liver, adipocytes, and muscle.
Regulation of macroautophagy
