Aminoglycosides

Question 1

Aminoglycosides

Answer 1

end in -mycin
cause nephrotoxicity and ototoxicity
destroy CN 8
used for gram negative bacteria

Question 2

How to monitor nephrotoxicity?

Answer 2

creatine and 24 creatinine

Question 3

how often do you give and how

Answer 3

q8hr
Given IM or IV
don’t give PO- not absorbed

Question 4

What is oral mycin used for?

Answer 4

Sterile the bowel
hepatic encephalopathy (liver coma)- ammonia level gets to high and cause coma
*goal is to reduce ammonia by killing e coli which increase ammonia
Bowel surgery- to sterilize
causes diarrhea

since not absorbed no otoxicity or nephrotoxicity

Question 5

Which drugs are used to sterilize bowel?

Answer 5

Neomycin and Kanamycin

Question 6

Troughs

Answer 6

drug is at the lowest concentration

Question 7

Peaks

Answer 7

drugs at the highest concentration

Question 8

TAP levels

Answer 8

Trough, administer, peak
used for the small difference between what works and what kills

Question 9

Digoxin

Answer 9

Small 0.125
Large: 0.25
draw TAP

Question 10

When to draw trough before giving next dose

Answer 10

30 min before

Question 11

Peak SUBL

Answer 11

5-10 min after dissolved

Question 12

Peak IV

Answer 12

15-30 min after drug is finished (empty bag)

Question 13

Peak IM

Answer 13

30-60 minutes

Question 14

Should you draw TAP levels on amnioglycosides ?

Answer 14

Yes