VIral hepatitis Flashcards
markers of hepatocyte inflammation? of biliary tree inflammation?
ALT and AST elevation. Alk Phos and GGT elevation
Which (A-E) viruses are chronic? what type of genetic material? Pattern of transmission?
BCD can be chronic (esp C). All except B (dsDNA) are ssRNA. BCD are blood/sexual/parenteral which AE are fecal oral
E’s of HEV
enteric, expectant mothers, epidemic (waterborne)
what type of virus are Hep A-E
Picorna, hepadna, flavi, delta, hepe
incubation period for Hep A-E
A-short, B-long, C-long, D-short superinfect and long co-infect, E-short
ground glass appearing hepatocytes
Hep B surface Ag in cytoplasm
cut off for acute/chronic HBV infection
6 months
Significance of Anti-HAV IgM and IgG serum markers
IgM- best test for active hepA. IgG- prior HAV infection and/or vaccination
Significance of HBsAg, Anti-HBs
indicates HepB infection.
Indicates immunity to hepB (recovered (will have Anti-HBc) or immunized)
Anti-HBc: IgM and IgG.
IgM- acute/recent infection.
IgG- prior exposure or chronic infection. Positive during window period
Window period
month in between when HBsAg become indetectable and Anti-HBs become detecatable. Anti-HBc positive during this time.
HBeAg and Anti-HBe
second antigenic determinant in HBV core. Indicates active viral replication (high transmissibility)
Indicates low transmissibility
ALT>AST, AST>ALT
viral hepatitis, alcoholic hepatitis
Markers of HBV infection in the order they appear
SECES: SE antigens, CES antibodies
which hepatitis virus is most commonly sexually transmitted? how would it present? which is most commonly associated with blood transfusion
HBV, jaundice
HCV
