Platelet and Vascular Disorders Flashcards
Thrombotic thrombocytopenic purpura (TTP) is
characterized by:
A. Prolonged PT
B. Increased platelet aggregation
C. Thrombocytosis
D. Prolonged APTT
B
Thrombocytopenia may be associated with:
A. Postsplenectomy
B. Hypersplenism
C. Acute blood loss
D. Increased proliferation of pluripotential stem
cells
B
. Aspirin prevents platelet aggregation by inhibiting
the action of which enzyme?
A. Phospholipase
B. Cyclo-oxygenase
C. Thromboxane A2 synthetase
D. Prostacyclin synthetase
B
Normal platelet adhesion depends upon:
A. Fibrinogen
B. Glycoprotein Ib
C. Glycoprotein IIb, IIIa complex
D. Calcium
B
Which of the following test results is normal in a
patient with classic von Willebrand’s disease?
A. Bleeding time
B. Activated partial thromboplastin time
C. Platelet count
D. Factor VIII:C and von Willebrand’s factor
(VWF) levels
C
- Bernard–Soulier syndrome is associated with:
A. Decreased bleeding time
B. Decreased factor VIII assay
C. Thrombocytopenia and giant platelets
D. Abnormal platelet aggregation to ADP
C
When performing platelet aggregation studies,
which set of platelet aggregation results would most likely be associated with Bernard–Soulier syndrome?
A. Normal platelet aggregation to collagen, ADP,
and ristocetin
B. Normal platelet aggregation to collagen, ADP, and epinephrine; decreased aggregation to ristocetin
C. Normal platelet aggregation to epinephrine and
ristocetin; decreased aggregation to collagen
and ADP
D. Normal platelet aggregation to epinephrine,
ristocetin, and collagen; decreased aggregation
to ADP
B
Which set of platelet responses would be most
likely associated with Glanzmann’s
thrombasthenia?
A. Normal platelet aggregation to ADP and
ristocetin; decreased aggregation to collagen
B. Normal platelet aggregation to collagen;
decreased aggregation to ADP and ristocetin
C. Normal platelet aggregation to ristocetin;
decreased aggregation to collagen, ADP, and
epinephrine
D. Normal platelet aggregation to ADP; decreased
aggregation to collagen and ristocetin
C
Which of the following is a characteristic of acute
immune thrombocytopenic purpura?
A. Spontaneous remission within a few weeks
B. Predominantly seen in adults
C. Nonimmune platelet destruction
D. Insidious onset
A
TTP differs from DIC in that:
A. APTT is normal in TTP but prolonged in DIC
B. Schistocytes are not present in TTP but are
present in DIC
C. Platelet count is decreased in TTP but normal
in DIC
D. PT is prolonged in TTP but decreased in DIC
A
Which of the following is a characteristic of acute
immune thrombocytopenic purpura?
A. Spontaneous remission within a few weeks
B. Predominantly seen in adults
C. Nonimmune platelet destruction
D. Insidious onset
A
TTP differs from DIC in that:
A. APTT is normal in TTP but prolonged in DIC
B. Schistocytes are not present in TTP but are
present in DIC
C. Platelet count is decreased in TTP but normal
in DIC
D. PT is prolonged in TTP but decreased in DIC
A
Several hours after birth, a baby boy develops
petechiae and purpura and a hemorrhagic
diathesis. The platelet count is 18 × 109/L. What is
the most likely explanation for the low platelet
count?
A. Drug-induced thrombocytopenia
B. Secondary thrombocytopenia
C. Neonatal alloimmune thrombocytopenia
D. Neonatal DIC
C
Several hours after birth, a baby boy develops
petechiae and purpura and a hemorrhagic
diathesis. The platelet count is 18 × 109/L. What is
the most likely explanation for the low platelet
count?
A. Drug-induced thrombocytopenia
B. Secondary thrombocytopenia
C. Neonatal alloimmune thrombocytopenia
D. Neonatal DIC
C
Which of the following is associated with
post-transfusion purpura (PTP)?
A. Nonimmune thrombocytopenia/alloantibodies
B. Immune-mediated thrombocytopenia/
alloantibodies
C. Immune-mediated thrombocytopenia/
autoantibodies
D. Nonimmune-mediated thrombocytopenia/
autoantibodies
B
