cancer

Question 1

monoclonal antibodies ( mAbs)

Answer 1

works outside the cell at the receptor site

increase the body’s own immune system

Question 2

drug example of mAbs

Answer 2

infliximab
rituximab

Question 3

common use of monoclonal antibodies (mAbs )

Answer 3

asthma
Rheumatoid arthritis
psoriasis
breast cancer

Question 4

tyrosine kinase inhibitors (Nibs)

Answer 4

Work inside the cell

blocks tyrosine kinase that signals cell growth

Question 5

example of Nibs

Answer 5

alectinib
cobimetinib
lenvatinib

Question 6

Common use for Nibs

Answer 6

Hepatocellular carcinoma
renal cell carcinoma
melanoma

Question 7

Proteasome inhibitors (Mibs)

Answer 7

works inside the cell

blocks proteasome that breakdown unwanted proteins

Question 8

common use of Mibs

Answer 8

Multiple myeloma

Mantle cell lymphoma

Question 9

Omalizumab ( Xolair )

Answer 9

first mab approved to treat allergy-related asthma

binds to free igE, therefore, reducing available igE to bind to the receptor on the surface of mast cells.
reduce inflammatory response caused by mast cell activation

Question 10

Omalizumab ( Xolair )

Answer 10

first mab approved to treat allergy-related asthma

binds to free igE, therefore, reducing available igE to bind to the receptor on the surface of mast cells.
reduce inflammatory response caused by mast cell activation

Question 11

interleukin antagonist

Answer 11

Mepolizumab (Nucala)

Benralziumab ( Fasenra)
Reslizumab (Cinqair)

tx for eosinophilic asthma

binds to IL-5 that is responsible for the function and survival of eosinophils; hence IL-5 can not bind to the receptor on eosinophils, therefore decreasing their production and survival