AUTOIMMUNE DISEASES

Question 1

Mechanisms of tolerance

Answer 1

Central tolerance
Peripheral tolerance

Question 2

Central tolerance for T cells

Answer 2

Positive selection
Negative selection (AIRE)

Question 3

Mechanisms of peripheral tolerance

Answer 3

Ignorance
Anergy
Suppression
Deletion

Question 4

Central and peripheral tolerance of B cells

Answer 4

Immunoglobulin rearrangements
Interaction with the stromal cells of the bone marrow
Receptor editing or apoptosis
Too low affinity > anergy

Ability of recognition of the IgG: low ability, inhibitor receptors or high ability, apoptosis or anergy

Importance of T cells

Question 5

Autoimmune disease classification

Answer 5

Type II
Type III
Type IV

Question 6

Factors that can favor the onset of autoimmune diseases

Answer 6

Genetic defects/predisposition
Environmental factors: inflammation, infections, drugs, smoking.

Question 7

APECED

Answer 7

AIRE deficiency

Question 8

IPEX

Answer 8

FoxP3 deficiency

Question 9

ALPS

Answer 9

FAS deficiency