46 Anemia associated with Marrow Infiltration Flashcards
Refers to anemia resulting from the presence of spotty to massive marrow infiltration with abnormal cells or tissue components
Best reserved for marrow replacement by nonhematologic tumors and nonhematopoietic entities
Myelophthisic anemia
Referred to as findings accompanied by teardrop-shaped red cells (dacrocytes), nucleated red cells, and immature myeloid cells
Leukoerythroblastic reaction
Invasion is the primary process of metastasis and occurs often as a result of loss of ________
E-cadherin
Most common cancers that metastasize to the marrow
Cancers of the lung, breast, and prostate
Morphologic picture consists of cell debris and occasional necrotic cells in an eosinophilic amorphus background
Marrow necrosis
Most common underlying cause of marrow necrosis
Metastatic tumors, acute lymphoblastic leukemia (children), and septicemia
The most characteristic blood feature of Myelophthisic anemia
Disturbed morphologic appearance of red cells on the blood film
**the presence of teardrop forms and nucleated red cells is particularly suggestive of marrow infiltration
The most reliable procedure used to diagnose marrow-infiltrative disease and should be performed in all patients with suspected metastatic carcinoma or hematologic features of myelophthisic anemia.
Marrow biopsy
Reliably identifies marrow infiltration by Gaucher cells
Technetium-99m (99mTc) sestamibi uptake
Helpful for defining the severity of marrow replacement and is being used with increasing frequenc
Magnetic resonance imaging (MRI)
MRI findings in marrow necrosis
Extensive, diffuse, geographic pattern of signal abnormality consisting of a central area of variable signal intensity surrounded by a distinct peripheral enhancing rim
The goal of treatment in Myelophthisic anemia
Manage the underlying disease
