Fibroblastic and Remodeling Phase - Class 1

Question 1

fibroblastic stage

Answer 1

formation of collagen and repair of CT

Question 2

fibroblastic stage overlaps w/

Answer 2

inflammatory phase and epithelization

Question 3

how long does the fibroblastic stage last

Answer 3

2-3 days to 2-4 weeks

Question 4

what is the quality of the scar determined by

Answer 4

fibroblastic phase

Question 5

what is the fibroblastic stage composed of

Answer 5

4 stages

Question 6

4 stages of fibroblastic stages

Answer 6

angiogenesis

collagen production

wound contraction

re-epithelialization

Question 7

angiogenesis (stages)

Answer 7

completion of this process

Question 8

collagen production

Answer 8

granulation tissue formation

Question 9

what does the fibroblastic stage consist of

Answer 9

rapid cell growth and replication

production of extracellular matrix (to fill the wound deficit)

wound resurfacing

Question 10

angiogenesis

Answer 10

creation of new blood supply by forming new blood vessels

increase circulation/remove waste and edema

Question 11

angioblasts

Answer 11

endothelial cells that make up blood vessel walls adjacent to the zone of injury

connect with other vessels to form new capillary loops

Question 12

fibroblasts

Answer 12

aid in formation of granulation tissue

Question 13

granulation tissue

Answer 13

temporary lattice of vascularized CT that fills the defect of the wound

as it matures it is replaced by scar tissue

Question 14

the hallmark of tissue repair

Answer 14

formation of granulation tissue

Question 15

what does granulation tissue consist of

Answer 15

proliferating fibroblasts and vascular endothelial cells

occurs int he first 24-72 hours of the repair process

Question 16

wound contraction

Answer 16

draws margins together

myofibroblasts are the driving force

begins on day 4 and ends in 2-3 weeks

Question 17

what type of wounds contract faster

Answer 17

linear wounds

Question 18

which wounds contract slower

Answer 18

circular wounds

Question 19

re-epithelialization/scar formation

Answer 19

keratinocytes migrate across the wound surface

epithelial cells cannot migrate over nonviable tissues –> they must reach O2 rich scaffolding of the granulation tissue

re-establish surface cover

Question 20

when is the fibroblastic phase complete

Answer 20

when wound is resurfaced

Question 21

fxn of the remodeling phase

Answer 21

maturation of scar tissue

granulation tissue matrix is strengthened and reorganized

Question 22

when is there successful completion of the remodeling phase

Answer 22

wound is closed

sufficient tensile strength

mimic normal

Question 23

sufficient tensile strength

Answer 23

early on only 15%

forces applied in graded fashion

Question 24

mimic normal

Answer 24

alignment

orientation

tensile strength

mobility

scar looks like the rest of the skin

Question 25

successful remodeling phase requires

Answer 25

good synthesis/lysis balance

production of new collagen

removing of old collagen

Question 26

2 theories of new collagen

Answer 26

induction theory

tension theory

Question 27

induction theory

Answer 27

less common

scar tissue mimics tissue surrounding it

Question 28

tension theory

Answer 28

new collagen is

-laid down according to stress/tension on tissue
-w/o stress
-laid down in haphazard direction with less fiber distance
-results in cross-linking

Question 29

adhesions

Answer 29

with loss of H2O –> critical fiber distance is decreased

with immobilization –> movement and stress decreased