Blood products

Question 1

What is depleted in irradiated blood?

Answer 1

T-lymphocytes

=> avoid transfusion-associated graft versus host disease

Question 2

When are CMW negative blood components required?

Answer 2

• Granulocyte transfusions
• Intra-uterine transfusions
• Neonates up to 28 days post expected date of delivery
• During pregnancy (not labour/delivery)

Question 3

When should blood be irradiated?

Answer 3

• granulocyte transfusion
• IU transfusion
• neonates
• stem cell transplants
• patients on certain chemotherapy (purine analogue)
• Hodgkin lymphoma

Question 4

When is FFP most commonly used?

Answer 4

prophylactically in patients undergoing invasive surgery where there is a risk of significant bleeding

Question 5

Universal donor of FFP?

Answer 5

AB blood type as no anti-A or anti-B antibodies in plasma

Question 6

What composes cryoprecipitate?

Answer 6

concentrated Factor VIII:C
von Willebrand factor
fibrinogen
Factor XIII
Fibronectin

Question 7

What is cryoprecipitate used to replace?

Answer 7

fibrinogen

Question 8

When is cryoprecipitate used?

Answer 8

fibrinogen < 1.5 g/L
- DIC
- Liver failure
- hypofibrinogenaemia
- haemophilia (if factors unavailable)
- von Willebrand
- prophylactic in patients undergoing invasive surgery with increased bleeding risk

Question 9

When is Prothrombin complex concentrate used?

Answer 9

• emergency reversal of anticoagulation in patients with:

1. severe bleeding
2. head injury with suspected intracerebral haemorrhage