—-

Question 1

Azidothymidine (AZT) and Didanosine (ddl)

Answer 1

Both are nucleoside analogs that both lack a free 3’ hydroxyl (-OH) group. These drugs have high affinity for reverse transcriptase enzyme and inhibit their activity. They are therefore used in the treatment of retro-viral infections such as HIV.

Question 2

Acyclovir

Answer 2

Possesses an open chain structure in place of the pentose sugar ring structure. Acyclovir is a potent inhibitor of viral DNA polymerase and causes termination of DNA replication. It is used in the treatment of Herpes virus.

A nucleoside analog.

Question 3

At the periphery of the nucleus.

Answer 3

Marginal chromatin

Part of herterochromatin

Question 4

Discrete bodies of chromatin of irregular in size and shape that are found throughout the nucleus.

Answer 4

Karyosomes

Question 5

Found in association with the nucleolus

Answer 5

Nucleolus-associated chromatin

Question 6

Ions and molecules <9nm (less than 9 nm) to diffuse freely through [this] space.

Ions and molecules >9nm (greater than 9 nm) must be transported by active transport through [this] space.

Answer 6

Nuclear Pore Complex (NPC)

Question 7

Membrane-bound blood proteins that are vital to drug detoxification, cell metabolism and homeostasis. Hepatocytes and detoxification enzymes assoc with Liver and Smooth Endoplasmic Reticulum (sER)

Answer 7

Cytochrome P450 system.