Ichthyosis

Question 1

Characteristics of Ichthyosis

Answer 1

excessive hyperkeratosis on all skin surfaces including the digital, carpal, and tarsal pads

Question 2

What is the gene involved in congenital ichthyosis of golden retrievers?

Answer 2

autosomal recessive PNPLA 1 gene

Question 3

Histopath features of ichthyosis

Answer 3

epidermis normal to mildly hyperplasticity but the hyperplasia can be marked (some cases especially chronic), epidermal hyperpigmentation variable; marked compact orthokeratotic hyperkeratosis and follicular orthokeratotic keratosis and plugging; one of the most characteristic changes is marked hypergranulosis but this layer may be normal, thin, or irregular; mitotic figures may be numerous